Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Therapy Resistance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Tumor-Associated Macrophages And Microglia | contributes_to | cell_type | 0.90 |
| p53 mutants | causes | protein | 0.90 |
| DNA Methylation | contributes_to | process | 0.90 |
| Histone Modifications | contributes_to | process | 0.90 |
| Glioma Stem Cells | contributes_to | cell_type | 0.90 |
| Pi3K/Akt/Mtor | contributes_to | pathway | 0.85 |
| Glioblastoma | associated_with | disease | 0.85 |
| Therapy-Induced Evolution | contributes_to | process | 0.85 |
| PI3K/Akt/mTOR Signaling Pathway | contributes_to | pathway | 0.85 |
| Glioblastoma Metabolism | contributes_to | process | 0.85 |
| Tumor Heterogeneity | contributes_to | phenotype | 0.85 |
| Immune Evasion | contributes_to | mechanism | 0.85 |
| CAV1 | associated_with | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity