disease

Glioblastoma

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Glioblastoma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2940Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Glioblastoma is a disease characterized by neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with Aging, Als, Alzheimer. Connected to 715 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	IDH1, VAMP8, LAMP2, GBM, LC3, EPG5, STX17, SQSTM1
Therapeutic Agents	Cystamine Dihydrochloride, Immunotherapy, Oncolytic Viral Therapy, Mt-125, Glucocorticoids, YB-3-17
KG Connections	1119 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    Glioblastoma["Glioblastoma"] -->|"associated"| Autophagy["Autophagy"]
    Glioblastoma["Glioblastoma"] -->|"activates"| Cholesterol["Cholesterol"]
    Glioblastoma["Glioblastoma"] -->|"associated"| Lipid_Metabolism["Lipid Metabolism"]
    Glioblastoma["Glioblastoma"] -->|"activates"| Circadian_Rhythm["Circadian Rhythm"]
    Glioblastoma["Glioblastoma"] -->|"activates"| Complement["Complement"]
    Glioblastoma["Glioblastoma"] -->|"activates"| Akt["Akt"]
    IDH1["IDH1"] -->|"associated"| Glioblastoma["Glioblastoma"]
    IDH2["IDH2"] -.->|"inhibits"| Glioblastoma["Glioblastoma"]
    VAMP8["VAMP8"] -->|"associated"| Glioblastoma["Glioblastoma"]
    LAMP2["LAMP2"] -->|"associated"| Glioblastoma["Glioblastoma"]
    style Glioblastoma fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1061)

Target	Relation	Type	Str
Cranial Bone Marrow	associated_with	cell_type	0.90
Brain Tumor	associated_with	disease	0.90
Mtor	activates	pathway	0.90
Autophagy	activates	pathway	0.90
Tumor Microenvironment	therapeutic_target	pathway	0.90
Therapy Resistance	associated_with	phenotype	0.85
Circadian Rhythms	interacts_with	process	0.85
Metabolic Resistance	causes	phenotype	0.80
Immunosuppression	associated_with	phenotype	0.80
Immune System	associated_with	process	0.80
Mtor	therapeutic_target	pathway	0.80
Stem Cell	therapeutic_target	pathway	0.80
Invasion	activates	pathway	0.80
Invasion	regulates	pathway	0.80
Blood-Brain Barrier	therapeutic_target	pathway	0.80
Wnt	activates	pathway	0.80
Pi3K/Akt	therapeutic_target	pathway	0.80
Cholesterol	activates	pathway	0.70
Lipid Metabolism	associated_with	pathway	0.70
Angiogenesis	therapeutic_target	pathway	0.70
Immune Response	therapeutic_target	pathway	0.70
Apoptosis	activates	pathway	0.70
Epigenetic	regulates	pathway	0.70
Nf-Κb	activates	pathway	0.70
Cell Cycle	activates	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Dna Methylation	treats	pathway	0.70
Neurogenesis	activates	pathway	0.70
Erk Signaling	activates	pathway	0.70
Stem Cell	activates	pathway	0.70
Epigenetic	expressed_in	pathway	0.70
Angiogenesis	activates	pathway	0.65
Pi3K/Akt	activates	pathway	0.65
Autophagy	associated_with	pathway	0.60
Circadian Rhythm	activates	pathway	0.60
Complement	activates	pathway	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
Epigenetic	associated_with	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Autophagy	inhibits	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
Insulin Signaling	therapeutic_target	pathway	0.60
Cholesterol	therapeutic_target	pathway	0.60
Glycolysis	therapeutic_target	pathway	0.60
Mitophagy	inhibits	pathway	0.60
Oxidative Phosphorylation	inhibits	pathway	0.60
Mapk	associated_with	pathway	0.60

Incoming (1879)

Source	Relation	Type	Str
GBM	associated_with	gene	1.00
GBM	therapeutic_target	gene	1.00
CANCER	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
EGFR	activates	gene	1.00
GLIOBLASTOMA	associated_with	gene	1.00
GLIOBLASTOMA	activates	gene	1.00
GLIOBLASTOMA	therapeutic_target	gene	1.00
GLIOBLASTOMA	inhibits	gene	1.00
GLIOBLASTOMA	regulates	gene	1.00
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	associated_with	disease	1.00
NEURODEGENERATION	activates	gene	1.00
Tumor	activates	disease	1.00
Als	activates	disease	1.00
Cancer	activates	disease	1.00
Als	therapeutic_target	disease	1.00
MTOR	activates	gene	0.95
PI3K	activates	gene	0.95
PI3K	therapeutic_target	gene	0.95
AKT	therapeutic_target	gene	0.95
GBM	activates	gene	0.95
AUTOPHAGY	activates	gene	0.95
Glioma	associated_with	disease	0.95
Neurodegeneration	activates	disease	0.95
Glioma	activates	disease	0.95
Pi3K/Akt/Mtor	involved_in	pathway	0.95
Glioblastoma Stem Cells	involved_in	cell_type	0.95
Glucocorticoids	modulates	compound	0.95
GR	regulates	receptor	0.95
PI3K/Akt/mTOR	upregulates	pathway	0.95
Lipid Metabolism	promotes	pathway	0.95
Compound 1F	suppresses	compound	0.95
IDH2	associated_with	gene	0.92
Lipid Metabolism	contributes_to	pathway	0.90
WNT10A	associated_with	gene	0.90
Mt-125	treats	drug	0.90
De Novo Lipid Synthesis	associated_with	process	0.90
PI3K/AKT/MTOR	upregulates	pathway	0.90
Axonal Injury	associated_with	process	0.90
Clock Gene Expression	involved_in	phenotype	0.90
Glycolytic Flux	contributes_to	process	0.90
mTOR	associated_with	protein	0.90
GSPT1	associated_with	gene	0.90
PTEN Deficiency	associated_with	biomarker	0.90
Cranial Bone Marrow	associated_with	brain_region	0.90
Lactate	contributes_to	compound	0.90
SREBP1	promotes	gene	0.90
CLDN3	promotes	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

neuro-oncology | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Glioblastoma

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

CREB Signaling in Neurodegeneration

Exosome and Extracellular Vesicle Brain Delivery

bbb-transport-mechanisms

Exosome-Based Drug Delivery for CBS/PSP

Litronesib (LY317615/Enzastaurin)

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

RRAGB — Ras-Related GTP Binding B

PDCD10 Gene (Programmed Cell Death 10)

TERT Gene

TrkB Protein

slc22a1

Sirtuin Signaling Pathway

NanoCarrier Co., Ltd.

Megalencephalic Leukodystrophy

H3F3B Gene — H3.3 Histone B

FZD10 Gene

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

NNMT Gene