gene

CAV1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAV1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

517Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CAV1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Als, Alzheimer. Connected to 119 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CAV1
Aliases	Caveolin 1, Caveolin-1
Protein Type	Structural Protein
Target Class	Structural Protein
Function	No established drugging mechanism for structural membrane protein
Mechanism of Action	No established drugging mechanism for structural membrane protein
Druggability	Low (0.35)
Clinical Stage	Approved
Molecular Weight	22 kDa
Pathways	MAPK pathway, PI3K
UniProt ID	Q2TNI1
GeneCards	CAV1
Human Protein Atlas	CAV1
Pathway	Regulation
PI3K/Akt	Inhibits/activates
Associated Diseases	ALS, ALZHEIMER, Anxiety, Atherosclerosis
Known Drugs/Compounds	Daidzein
Interactions	TFR1, LRP1, ABCB1, HIF1A, BECN1, CLDN5
SciDEX Target	View Target Profile (1 clinical trials)
KG Connections	517 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CAV1 — AlphaFold Q2TNI1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CAV1["CAV1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CAV1["CAV1"] -->|"interacts"| TFR1["TFR1"]
    CAV1["CAV1"] -->|"interacts"| LRP1["LRP1"]
    CAV1["CAV1"] -->|"interacts"| ABCB1["ABCB1"]
    CAV1["CAV1"] -->|"co discussed"| ABCB1_1["ABCB1"]
    CAV1["CAV1"] -->|"co discussed"| FCGRT["FCGRT"]
    TFR1_2["TFR1"] -->|"interacts"| CAV1["CAV1"]
    LRP1_3["LRP1"] -->|"interacts"| CAV1["CAV1"]
    ABCB1_4["ABCB1"] -->|"interacts"| CAV1["CAV1"]
    LRP1_5["LRP1"] -->|"co discussed"| CAV1["CAV1"]
    style CAV1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (378)

Target	Relation	Type	Str
CLDN5	mediates	protein	0.90
Cytosolic CLDN5 Aggregation	causes	phenotype	0.90
Blood-Brain Barrier Disruption	contributes_to	phenotype	0.87
CLDN5 Redistribution	mediates	process	0.85
CLDN5	regulates	gene	0.85
Retinal Ganglion Cell Senescence	mediates	process	0.85
Retinal Ganglion Cell Senescence	upregulates	process	0.85
BACE1	modulates	protein	0.85
endothelial barrier integrity	regulates	process	0.80
caveolin_1	encodes	protein	0.80
interstitial fibrosis and tubular atrophy	associated_with	phenotype	0.75
oxidative stress response	participates_in	pathway	0.70
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Ms	regulates	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Ms	contributes_to	disease	0.65
Als	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	expressed_in	disease	0.65
ALS	activates	disease	0.65
Infection	associated_with	disease	0.65
Ms	causes	disease	0.65
Als	causes	disease	0.65
Glaucoma	causes	disease	0.65
ALS	phosphorylates	disease	0.65
Cancer	causes	disease	0.65
Fibrosis	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Als	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Glioblastoma	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Aging	contributes_to	disease	0.65
Parkinson	contributes_to	disease	0.65
Als	regulates	disease	0.65

Incoming (139)

Source	Relation	Type	Str
AUTOPHAGY	degrades	entity	0.95
Autophagy	degrades	process	0.90
HYPOXIA	activates	entity	0.90
h-84808267	targets_gene	hypothesis	0.90
Hypoxia	activates	process	0.85
Autophagy	downregulates	process	0.85
h-84808267	targets	hypothesis	0.80
HSPA8	degrades	gene	0.80
Hypoxia	upregulates	process	0.80
autophagy	degrades	process	0.80
TFR1	interacts_with	gene	0.65
LRP1	interacts_with	gene	0.65
ABCB1	interacts_with	gene	0.65
OCLN	activates	gene	0.60
BECN1	activates	gene	0.60
CLDN5	activates	gene	0.60
CALB1	associated_with	gene	0.60
KCNN3	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
CACNA2D4	inhibits	gene	0.60
HIF1A	activates	gene	0.60
PECAM1	associated_with	gene	0.60
IL6	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
FOS	associated_with	gene	0.60
PI3K	expressed_in	gene	0.60
MTOR	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
MTOR	activates	gene	0.60
FIP200	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
HSP90AA1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
OPTN	causes	gene	0.60
LCAT	interacts_with	protein	0.60
TRAF4	interacts_with	protein	0.60
GBA	regulates	gene	0.60
GEM	activates	gene	0.60
ANGPT1	activates	gene	0.60
HDAC2	activates	gene	0.60
PRKACA	inhibits	gene	0.60
GBM	associated_with	gene	0.60
AKT	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
AGO2	interacts_with	gene	0.60
STAT3	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
SPHK1	regulates	gene	0.60
LIF	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CAV1

Understanding Entity Pages

Summary

Wiki Pages (21)

CAV1

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

calcium-dysregulation-comparison

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

nimodipine-als

Blood-Brain Barrier Dysfunction in Neurodegeneration

APOC4 — Apolipoprotein C-IV

Blood-Brain Barrier Biology and Crossing Strategies

substantia-nigra

vitamin-d-therapy-neurodegeneration

Ion Channel Dysfunction in Huntington's Disease

Calcium Signaling Dysregulation in Parkinson's Disease

Exosome and Extracellular Vesicle Brain Delivery

Calcium Signaling Dysregulation in Neurodegeneration

ventral-anterior-thalamic-nucleus

Calcium Dysregulation in Neurodegeneration

JPH2 — Junctophilin 2

iron-calcium-glymphatic-convergence-alzheimers

Calcium Signaling Dysregulation in Alzheimer's Disease

Blood-Brain Barrier Breakdown in Neurodegeneration

Pathway Diagram

Outgoing (378)

Incoming (139)

Targeting Hypotheses (0)

Mentioning Analyses (1)

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (0)