Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBE2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Ubiquitin-conjugating enzyme E2 A involved in protein quality control, DNA repair, and neurodegenerative diseases
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| Gene Symbol | UBE2A |
| Full Name | Ubiquitin-Conjugating Enzyme E2 A |
| Chromosome | Xq24 |
| Protein Family | Ubiquitin-conjugating enzyme (E2) family |
| Protein Type | Enzyme |
| Function | is a member of the E2 ubiquitin-conjugating enzyme family located on chromosome Xq24. |
| Primary Expression | Ubiquitous; high in brain, hippocampus, cortex, dopaminergic neurons |
| Molecular Weight | 17 kDa |
| Amino Acids | 152 aa |
| UniProt ID | P49411 |
| NCBI Gene ID | 7326 |
| Ensembl ID | ENSG00000100906 |
| OMIM | 300860 |
| GeneCards | UBE2A |
| Human Protein Atlas | UBE2A |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
UBE2A["UBE2A"]
neurodegeneration["neurodegeneration"]
UBE2A -->|"implicated_in"| neurodegeneration
style UBE2A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning UBE2A in their description or question text
No additional research found