Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UNC13B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
UNC13B encodes Munc13-2, a critical synaptic protein involved in synaptic vesicle priming, neurotransmitter release, and short-term plasticity. Implicated in Alzheimer's disease, Parkinson's disease, and epilepsy.
| Gene Symbol | UNC13B |
| Full Name | UNC13 Homolog B (Munc13-2) |
| Chromosome | 9p13.3 |
| Molecular Weight | 200 kDa |
| Amino Acids | 735 aa |
| Exons | 37 |
| UniProt ID | [Q9Y5S4](https://www.uniprot.org/uniprot/Q9Y5S4) |
| Ensembl ID | ENSG00000075643 |
| GeneCards | UNC13B |
| Human Protein Atlas | UNC13B |
| Munc13-2 (full-length) | Contains all domains including the C1 domain, allowing phorbol ester-responsive regulation |
| Munc13-2B | Lacks the C1 domain, resulting in reduced activity-dependent modulation |
| Associated Diseases | Epilepsy |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
UNC13B["<b>UNC13B</b>"]
TREM2["TREM2"]
UNC13B -->|"associated with"| TREM2
OxPC["OxPC"]
UNC13B -->|"associated with"| OxPC
microglia["microglia"]
UNC13B -->|"associated with"| microglia
neurodegeneration["neurodegeneration"]
UNC13B -->|"associated with"| neurodegeneration
UNC13B -->|"expressed in"| TREM2
UNC13B -->|"implicated in"| neurodegeneration
style UNC13B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||