Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about USP10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
USP10 is a member of the Ubiquitin Specific Peptidase (USP) family of deubiquitinating enzymes. It contains a conserved catalytic domain with the characteristic Cys, His, and Asp residues that form the catalytic triad.
| Gene Symbol | USP10 |
| Function | USP10 is a member of the Ubiquitin Specific Peptidase (USP) family of deubiquitinating enzymes. It contains a conserved catalytic domain with the characteristic Cys, His, and Asp residues that form... |
| Subcellular Localization | and substrate specificity, and a C-terminal domain that contributes to protein-p |
| GeneCards | USP10 |
| Human Protein Atlas | USP10 |
| Associated Diseases | esophageal squamous cell carcinoma |
| Known Drugs/Compounds | Spautin-1, FW-04-806 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
USP10["USP10"]
UBIQUITIN["UBIQUITIN"]
USP10 -->|"removes"| UBIQUITIN
ANLN["ANLN"]
USP10 -->|"deubiquitinates"| ANLN
Spautin_1["Spautin-1"]
Spautin_1 -->|"inhibits"| USP10
cytokinesis["cytokinesis"]
USP10 -->|"promotes"| cytokinesis
FW_04_806["FW-04-806"]
FW_04_806 -->|"inhibits"| USP10
esophageal_squamous_cell_carcinoma["esophageal squamous cell carcinoma"]
USP10 -->|"therapeutic_target"| esophageal_squamous_cell_carcinoma
style USP10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| UBIQUITIN | removes | protein | 0.95 |
| ANLN | deubiquitinates | protein | 0.95 |
| cytokinesis | promotes | process | 0.90 |
| esophageal squamous cell carcinoma | therapeutic_target | disease | 0.85 |
| DDX1 | degrades | protein | 0.85 |
| PRMT1 | associated_with | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||