gene

DDX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

45Outgoing

20Incoming

Summary

DDX1 encodes a DEAD-box RNA helicase essential for RNA metabolism, stress granule formation, and ALS/FTD pathogenesis through TDP-43 pathology. Over 20 PubMed references on structure, function, and disease associations.

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🧬 Gene Info

Gene Symbol	DDX1
Function	encodes an ATP-dependent RNA helicase that belongs to the highly conserved DEAD-box protein family.
Primary Expression	Hippocampus
Amino Acids	724 aa
Pathways	Amyloid
Ensembl ID	ENSG00000136531
GeneCards	DDX1
Human Protein Atlas	DDX1
Helicase activity	Unwinding of RNA duplexes
ATPase activity	ATP hydrolysis provides energy for conformational changes
RNA binding	Direct binding to various RNA substrates
Annealing activity	Can also promote RNA-RNA annealing
N-terminal extension	Contains nuclear localization signals
Associated Diseases	Alzheimer, Alzheimer'S Disease, Dementia, disease
Interactions	PRMT1, USP1
KG Connections	65 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DDX1["<b>DDX1</b>"]
    Alzheimer["Alzheimer"]
    DDX1 -->|"associated with"| Alzheimer
    Dementia["Dementia"]
    DDX1 -->|"associated with"| Dementia
    ALZHEIMER["ALZHEIMER"]
    DDX1 -->|"associated with"| ALZHEIMER
    PSEN1["PSEN1"]
    DDX1 -->|"associated with"| PSEN1
    MICROGLIA["MICROGLIA"]
    DDX1 -->|"associated with"| MICROGLIA
    DEMENTIA["DEMENTIA"]
    DDX1 -->|"associated with"| DEMENTIA
    TGM2["TGM2"]
    DDX1 -->|"therapeutic target"| TGM2
    GBA["GBA"]
    DDX1 -->|"associated with"| GBA
    GRN["GRN"]
    DDX1 -->|"associated with"| GRN
    Microglia["Microglia"]
    DDX1 -->|"associated with"| Microglia
    Amyloid["Amyloid"]
    DDX1 -->|"associated with"| Amyloid
    SORL1["SORL1"]
    SORL1 -->|"associated with"| DDX1
    ABCA7["ABCA7"]
    ABCA7 -->|"associated with"| DDX1
    ADAM10["ADAM10"]
    ADAM10 -->|"associated with"| DDX1
    GRN["GRN"]
    GRN -->|"associated with"| DDX1
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"associated with"| DDX1
    GENES["GENES"]
    GENES -->|"associated with"| DDX1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| DDX1
    AND["AND"]
    AND -->|"associated with"| DDX1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| DDX1
    TGM2["TGM2"]
    TGM2 -->|"associated with"| DDX1
    PSEN1["PSEN1"]
    PSEN1 -->|"associated with"| DDX1
    AMYLOID["AMYLOID"]
    AMYLOID -->|"associated with"| DDX1
    Hippocampus["Hippocampus"]
    DDX1 -->|"expressed in"| Hippocampus
    Microglia["Microglia"]
    DDX1 -->|"expressed in"| Microglia
    neurodegeneration["neurodegeneration"]
    DDX1 -->|"implicated in"| neurodegeneration

Outgoing (45)

Target	Relation	Type	Str
Cholangiocarcinoma	promotes	disease	0.95
Nuclear Localization	involved_in	process	0.90
PRMT1	upregulates	protein	0.85
Cholangiocarcinoma	biomarker_for	disease	0.85
USP1	upregulates	protein	0.85
hypoxia response	involved_in	process	0.80
Hypoxia Response	involved_in	pathway	0.75
Alzheimer	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
PSEN1	associated_with	gene	0.60
TGM2	therapeutic_target	gene	0.60
GBA	associated_with	gene	0.60
GRN	associated_with	gene	0.60
ADAM10	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
GBA	biomarker_for	gene	0.60
GRN	biomarker_for	gene	0.60
PSEN1	biomarker_for	gene	0.60
SORL1	biomarker_for	gene	0.60
TGM2	biomarker_for	gene	0.60
TGM2	targets	gene	0.60
SLCO1C1	targets	gene	0.60
NDNF	targets	gene	0.60
PRMT1	associated_with	gene	0.60
PRMT1	regulates	gene	0.60
PRMT1	activates	gene	0.60
PRMT1	targets	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
Microglia	associated_with	cell_type	0.60
Amyloid	associated_with	pathway	0.60
Alzheimer's disease	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
USP1	activates	gene	0.60
Hippocampus	expressed_in	brain_region	0.55
Microglia	expressed_in	cell_type	0.55
TGM2	associated_with	gene	0.50
SORL1	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
GRN	co_mentioned	gene	0.40
TGM2	co_mentioned	gene	0.40

Incoming (20)

Source	Relation	Type	Str
PRMT1	mediates	protein	0.95
PRMT1	phosphorylates	protein	0.90
USP10	degrades	protein	0.85
PRMT1	inhibits	protein	0.80
SORL1	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
ADAM10	associated_with	gene	0.60
GRN	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
GBA	associated_with	gene	0.60
ABCA7	biomarker_for	gene	0.60
ADAM10	biomarker_for	gene	0.60
DEMENTIA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DDX1

Understanding Entity Pages

Summary

Wiki Pages (7)

DDX1 Gene

gemin4

R-Loop Stress in Neurodegeneration

GEMIN3 Gene

DDX1 Protein