Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VCP-Mediated Autophagy Enhancement: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| VCP | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| VCP-Mediated Autophagy Enhancement | 0.415 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury vi [PMID:41800257] | Jin X, Xue H, Shi X, Zhou Y, Zhang J, Ze | International journal of biolo | 2026 | 0 |
| TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1 [PMID:41799849] | Camilleri JM, Zhang J, Wang T, Ahmad I, | Autophagy reports | 2026 | 0 |
| Ocular delivery of different valosin-containing protein (VCP) inhibitory formula [PMID:41617017] | Cao B, Almansa-Garcia AC, Sen M, Mühlfri | J Control Release | 2026 | 0 |
| STUB1-VCP/p97 limits PINK1 overaccumulation to safeguard mitophagy and memory. [PMID:41964371] | Lin JY, Huang ZB, Fang EF, Lu G | Autophagy | 2026 | 0 |
| Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mu [PMID:41909749] | Wang H, Jiang F, Pan A, Jin C, Xue Y, Li | Acta pharmaceutica Sinica. B | 2026 | 0 |
| Diagnostic performance of transcutaneous laryngeal ultrasound for vocal cord par [PMID:41134433] | Luo X, Xiong J, Liang S, Jiang Z, Chen H | Esophagus : official journal o | 2026 | 0 |
| The vital role of p97/valosin-containing protein-mediated degradation pathways i [PMID:41780115] | Phyu SM, Loh JXY, Zhao Y, Ramadan K | Current opinion in cell biolog | 2026 | 0 |
| STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels. [PMID:41903135] | Lin JY, Huang ZB, Zhang SQ, Wu Y, Cheng | Cell reports | 2026 | 0 |
| Nerve injury and vocal cord paralysis after esophageal atresia and tracheoesopha [PMID:41242420] | Soyer T, Akinci SM, Pişiren B, Arslan UE | Journal of pediatric surgery | 2026 | 0 |
| Valosin-Containing Protein as a therapeutic target in CAG repeat-driven Spinocer [PMID:41435767] | Singh S, Joshi D, Makani J, Singh S, Yad | Computational biology and chem | 2026 | 0 |
| Semi-automated Analysis of Beading in Degenerating Axons. [PMID:40272653] | ["V C P", "Pullarkat P"] | Neuroinformatics | 2025 | 0 |
| Vernix Caseosa Peritonitis: A Scoping Review. [PMID:41155773] | Augustin G, Herman M, Hrgović Z, Krešo A | Medicina (Kaunas, Lithuania) | 2025 | 0 |
| VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy. [PMID:38762759] | ["Wang Z", "Xiong S", "Wu Z", "Wang X", | Autophagy | 2024 | 0 |
| Neurodegenerative Disease Tauopathies. [PMID:37832941] | ["Creekmore B", "Watanabe R", "Lee E"] | Annual review of pathology | 2024 | 0 |
| Mitochondria ROS and mitophagy in acute kidney injury. [PMID:35678504] | ["Su L", "Zhang J", "Gomez H", "Kellum J | Autophagy | 2023 | 0 |