VCP

Understanding Entity Pages

This page aggregates everything SciDEX knows about VCP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

VCP is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AMI, Aging, Als. Connected to 279 entities in the SciDEX knowledge graph.

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flowchart TD
    VCP["VCP<br/>(Valosin-containing protein)"]
    
    autophagy["VCP-Mediated<br/>Autophagy Enhancement"]
    er_stress["ER Stress<br/>Pathway"]
    tau_prop["Tau Propagation"]
    
    TBK1["TBK1<br/>(TANK-binding kinase 1)"]
    CHMP2B["CHMP2B<br/>(Charged multivesicular<br/>body protein 2B)"]
    
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    FTD["Frontotemporal<br/>Dementia"]
    dementia["Dementia"]
    neurodegeneration["Neurodegeneration"]
    
    therapeutic["Therapeutic<br/>Target"]
    
    VCP --|"modulates"|--> autophagy
    VCP --|"regulates"|--> er_stress
    VCP --|"influences"|--> tau_prop
    VCP --|"activates"|--> TBK1
    VCP --|"activates"|--> CHMP2B
    
    VCP --|"activates"|--> ALS
    VCP --|"activates"|--> FTD
    VCP --|"activates"|--> dementia
    VCP --|"activates"|--> neurodegeneration
    
    autophagy --|"dysfunction leads to"|--> neurodegeneration
    er_stress --|"contributes to"|--> neurodegeneration
    tau_prop --|"promotes"|--> FTD
    
    TBK1 --|"regulates"|--> autophagy
    CHMP2B --|"involved in"|--> autophagy
    
    VCP --|"potential"|--> therapeutic
    
    style VCP fill:#006494
    style autophagy fill:#1b5e20
    style therapeutic fill:#1b5e20
    style er_stress fill:#ef5350
    style tau_prop fill:#ef5350
    style TBK1 fill:#4a1a6b
    style CHMP2B fill:#4a1a6b
    style ALS fill:#5d4400
    style FTD fill:#5d4400
    style dementia fill:#5d4400
    style neurodegeneration fill:#5d4400