gene

VGLUT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VGLUT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

VGLUT3 (SLC17A8) encodes a vesicular glutamate transporter enabling glutamate co-transmission in cholinergic and serotonergic neurons, essential for hearing.

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🧬 Gene Info

Gene Symbol	VGLUT3
Full Name	Vesicular Glutamate Transporter 3
Aliases	SLC17A8
Chromosome	12q23.1
Protein Type	Transporter
Function	is a unique vesicular glutamate transporter expressed primarily in cholinergic and serotonergic neurons, as well as some GABAergic neurons.
Primary Expression	cholinergic and serotonergic neurons, as well as some GABAergic neurons
Molecular Weight	62 kDa
Amino Acids	545 aa
UniProt ID	Q9P0U8
NCBI Gene ID	51287
Ensembl ID	ENSG00000101190
GeneCards	VGLUT3
Human Protein Atlas	VGLUT3
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VGLUT3 — AlphaFold Q9P0U8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VGLUT3 Gene

gene · 1054 words

→

VGLUT3 Protein

protein · 627 words

→

Pathway Diagram

graph TD
    VGLUT3["VGLUT3"]
    neurodegeneration["neurodegeneration"]
    VGLUT3 -->|"implicated_in"| neurodegeneration
    style VGLUT3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VGLUT3 in their description or question text

No additional research found