gene

VPS18

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about VPS18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

VPS18 encodes a core component of the HOPS complex essential for lysosomal fusion, autophagy, and protein clearance in neurons.

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🧬 Gene Info

Gene Symbol	VPS18
Full Name	Vacuolar Protein Sorting 18 homolog
Chromosome	15q14
Protein Type	Vesicle trafficking, HOPS complex subunit
Function	encodes a critical protein component of the HOPS (Homotypic fusion and Vacuole Protein Sorting) complex, which is essential for endosomal trafficking and lysosomal biogenesis[@huizing2005].
Amino Acids	796 aa
UniProt ID	Q9P258
NCBI Gene ID	8875
Ensembl ID	ENSG00000134882
GeneCards	VPS18
Human Protein Atlas	VPS18
RING finger domain	N-terminal RING finger involved in protein interactions
α-solenoid domain	Middle region mediates complex assembly
C-terminal domain	Interacts with other HOPS subunits
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VPS18 — AlphaFold Q9P258 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

VPS18 Gene

gene · 1566 words

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Pathway Diagram

graph TD
    VPS18["VPS18"]
    neurodegeneration["neurodegeneration"]
    VPS18 -->|"implicated_in"| neurodegeneration
    style VPS18 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning VPS18 in their description or question text

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