Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS53: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | VPS53 |
| Chromosome | 17p13.1 |
| Function | VPS53 (Vacuolar Protein Sorting 53 Homolog) is a component of the HOPS (Homotypic fusion and Vacuolar Protein Sorting) complex, which plays a critical role in lysosomal trafficking and autophagy. |
| Primary Expression | neurons and glial cells, with high expression in the cerebral cortex, [hippocampus](/brain-regions/hippo |
| Molecular Weight | 79 kDa |
| Amino Acids | 672 aa |
| Ensembl ID | ENSG00000156502 |
| GeneCards | VPS53 |
| Human Protein Atlas | VPS53 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
VPS53["VPS53"]
neurodegeneration["neurodegeneration"]
VPS53 -->|"implicated_in"| neurodegeneration
style VPS53 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning VPS53 in their description or question text
No additional research found