gene

WDR73

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WDR73: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive guide to WDR73 WD repeat protein in brain development, Galloway-Mowat syndrome, and neurodegeneration

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🧬 Gene Info

Gene Symbol	WDR73
Full Name	WD Repeat Domain 73
Chromosome	15q15.2
Protein Family	WD repeat proteins
Function	WD repeat domains: Typically 40-60 amino acid motifs ending in tryptophan-aspartic acid (W-D)
Primary Expression	neural progenitor cells of the developing brain and is involved in centrosome function, Wnt signaling, and regulation of apoptosis
Subcellular Localization	Primary localization: Nuclear
Amino Acids	60 aa
Pathways	Wnt signaling, Wnt
UniProt ID	Q8IYY8
NCBI Gene ID	203523
Ensembl ID	ENSG00000188021
GeneCards	WDR73
Human Protein Atlas	WDR73
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WDR73 — AlphaFold Q8IYY8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WDR73 Gene

gene · 1324 words

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Pathway Diagram

graph TD
    WDR73["WDR73"]
    neurodegeneration["neurodegeneration"]
    WDR73 -->|"implicated_in"| neurodegeneration
    style WDR73 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WDR73 in their description or question text

No additional research found