Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WNT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | WNT2 |
| Chromosome | 7q31.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | fetal lung and intestine, but has since been recognized as a crucial regulator of neural development and plasticity [@wodarz1998] |
| Molecular Weight | 37 kDa |
| Amino Acids | 360 aa |
| Exons | 4 |
| Pathways | Wnt, WNT |
| UniProt ID | Q9P315 |
| NCBI Gene ID | 7472 |
| Ensembl ID | ENSG00000105989 |
| GeneCards | WNT2 |
| Human Protein Atlas | WNT2 |
| Associated Diseases | neurodegeneration |
| Interactions | HER2, KRAS, WNT |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["WNT2"]
N1["HER2"]
N1 -->|"inhibits"| N0
N2["KRAS"]
N2 -->|"inhibits"| N0
N3["WNT"]
N3 -->|"inhibits"| N0
N4["neurodegeneration"]
N0 -->|"implicated in"| N4
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
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class N0 gene
class N1 gene
class N2 gene
class N3 gene| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning WNT2 in their description or question text
No additional research found