pathway

WNT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2940Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	WNT
Summary	Category page for companies developing WNT signaling, hedgehog, and developmental pathway therapies for Alzheimer's disease - includes WNT modulators, beta-catenin stabilizers, porcupine inhibitors, and developmental pathway targeting companies.
Key Genes/Proteins	AMYLOID, CTNNB1, PFKM, DKK1
Related Diseases	ALZHEIMER'S DISEASE
Linked Hypotheses	1 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WNT["WNT"] -->|"causes"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    WNT["WNT"] -->|"activates"| Carcinoma["Carcinoma"]
    WNT["WNT"] -->|"expressed in"| Cancer["Cancer"]
    WNT["WNT"] -->|"expressed in"| Tumor["Tumor"]
    WNT["WNT"] -->|"contributes to"| Tumor_1["Tumor"]
    WNT["WNT"] -->|"contributes to"| Cancer_2["Cancer"]
    FZD3["FZD3"] -->|"participates in"| WNT["WNT"]
    FZD3_3["FZD3"] -->|"binds"| WNT["WNT"]
    PSMB1["PSMB1"] -->|"activates"| WNT["WNT"]
    BECN1["BECN1"] -->|"activates"| WNT["WNT"]
    style WNT fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1045)

Target	Relation	Type	Str
neurogenesis	regulates	process	0.95
synaptic plasticity	regulates	process	0.95
Synapse Remodeling	regulates	process	0.90
Neurodevelopment	involved_in	process	0.90
neuroinflammation	regulates	process	0.90
PFKM	downregulates	protein	0.90
Autophagy	interacts_with	process	0.85
vascular remodeling	modulates	process	0.85
autophagy	suppresses	process	0.85
Alzheimer's Disease	protects_against	disease	0.85
Parkinson's Disease	protects_against	disease	0.85
Amyotrophic Lateral Sclerosis	protects_against	disease	0.85
stroke	protects_against	disease	0.85
Hepatocellular Carcinoma	causes	disease	0.80
Autism-Like Behaviors	mediates	phenotype	0.80
Wnt signaling	participates_in	pathway	0.80
autophagy	mediates	process	0.80
endothelial cells	expressed_in	cell_type	0.80
Alzheimer's disease	dysregulated_in	disease	0.80
Inhibitory Neuron	activates	cell_type	0.80
PULMONARY HYPERTENSION	involved_in	entity	0.75
Pulmonary Arterial Hypertension	involved_in	disease	0.75
embryo development	modulates	process	0.75
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
neural stem cells	activates	cell_type	0.70
neural stem cells	regulates	cell_type	0.70
glioblastoma	activates	disease	0.70
Carcinoma	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Tumor	contributes_to	disease	0.65
Cancer	contributes_to	disease	0.65
Cardiovascular	contributes_to	disease	0.65
Metabolic Syndrome	contributes_to	disease	0.65
Autoimmune	contributes_to	disease	0.65
Als	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Ischemia	activates	disease	0.65

Incoming (1895)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	0.98
Bnt162B2	associated_with	drug	0.95
CTNNB1	involved_in	gene	0.95
Thermal adaptation	inhibits	process	0.90
DKK1	inhibits	gene	0.90
Microglia	activates	cell_type	0.85
BNT162b2	modulates	drug	0.85
NOTUM	inhibits	gene	0.85
SFRP1	inhibits	gene	0.85
DVL3	regulates	gene	0.85
PARKINSON'S DISEASE	associated_with	disease	0.82
MTOR	associated_with	gene	0.82
PI3K	associated_with	gene	0.82
NF-KB	associated_with	protein	0.82
FZD3	participates_in	gene	0.80
GSK3B	inhibits	protein	0.80
APOE	associated_with	gene	0.74
AKT	associated_with	gene	0.74
PSMB1	activates	gene	0.70
ATG	activates	gene	0.70
ATG	regulates	gene	0.70
BECN1	regulates	gene	0.70
flavonoid	activates	compound	0.70
BECN1	activates	gene	0.66
LRRK2	associated_with	gene	0.66
LRP1	associated_with	gene	0.66
ALS	associated_with	disease	0.66
FUS	associated_with	gene	0.66
MTOR	activates	gene	0.66
TAU	associated_with	protein	0.66
EGFR	activates	gene	0.66
TAU	phosphorylates	protein	0.66
BDNF	activates	gene	0.66
AUTISM	expressed_in	disease	0.65
BDNF	expressed_in	gene	0.65
STING	expressed_in	gene	0.65
MAPK	mediates	gene	0.65
RAPAMYCIN	regulates	drug	0.65
HIPPOCAMPUS	phosphorylates	brain_region	0.65
APP	associated_with	gene	0.64
CFTR	activates	gene	0.60
CGAS	activates	gene	0.60
JNK	activates	gene	0.60
LDLR	regulates	gene	0.60
CANCER	mediates	disease	0.60
CARCINOMA	regulates	disease	0.60
GSK3B	regulates	gene	0.60
LAMP1	regulates	gene	0.60
RAS	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Inhibitory Neuron-Selective WNT Signaling Restoration	0.390	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positi [PMID:32248976]	Shen G, Gao Q, Liu F, Zhang Y, Dai M et	Biochem Biophys Res Commun	2020
WNT signalling in the normal human adult testis and in male germ cell neoplasms. [PMID:32667987]	Young JC, Kerr G, Micati D, Nielsen JE,	Hum Reprod	2020
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-cat [PMID:28811361]	Emons G, Spitzner M, Reineke S, Möller J	Mol Cancer Res	2017
Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. [PMID:24605829]	Meinhardt G, Haider S, Haslinger P, Proe	Endocrinology	2014
Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signa [PMID:15650056]	Tickenbrock L, Schwäble J, Wiedehage M,	Blood	2005

WNT

Understanding Entity Pages

Wiki Pages (21)

AD WNT Signaling and Developmental Pathway Companies

Novel Therapy Index

Parkinson's Disease

Parthanatos in Neurodegeneration

Therapeutics

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

NTF4 Protein

GSK-3β in Neurodegeneration

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Lithium for PSP/CBS — Phase 2 Trial

blood-brain-barrier

Spinal Cord Dorsal Horn Neurons

Niemann-Pick Disease Type C (NPC)

MACF1 — Microtubule-actin crosslinking factor 1

IGF-1 Signaling Pathway in Neurodegeneration

Cellular Reprogramming Therapies for Neurodegeneration

Notch Signaling Pathway in Neurodegeneration