concept

HER2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HER2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

341Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	HER2
Key Genes/Proteins	AKT, PI3K, EGFR Family, ERK
Related Diseases	Breast Cancer, Gastric Cancer, cancer
Related Pathways	oxidative stress response

Wiki Pages (16)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HER2["HER2"]
    style HER2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HER2 -->|"regulates"| Cell_Proliferation["Cell Proliferation"]
    HER2 -->|"regulates"| Cell_Survival["Cell Survival"]
    HER2 -->|"promotes"| cell_proliferation["cell proliferation"]
    HER2 -->|"promotes"| cell_survival["cell survival"]
    HER2 -.->|"biomarker for"| Breast_Cancer["Breast Cancer"]
    HER2 -->|"activates"| AKT([AKT])
    HER2 -->|"activates"| PI3K([PI3K])
    HER2 -->|"regulates"| cell_differentiation["cell differentiation"]
    HER2 -->|"target for"| cancer["cancer"]
    n_5A["5A"] -.->|"inhibits"| HER2
    trastuzumab{"trastuzumab"} -->|"target for"| HER2
    pertuzumab{"pertuzumab"} -->|"target for"| HER2
    EGFR([EGFR]) -->|"interacts"| HER2
    PI3K -.->|"inhibits"| HER2
    CANCER([CANCER]) -->|"target for"| HER2
    CDK4([CDK4]) -->|"target for"| HER2
    MTOR([MTOR]) -.->|"inhibits"| HER2
    AND([AND]) -->|"target for"| HER2
    AKT -.->|"inhibits"| HER2

Outgoing (198)

Target	Relation	Type	Str
Breast Cancer	associated_with	disease	0.98
Gastric Cancer	associated_with	disease	0.98
Cell Proliferation	regulates	process	0.95
Cell Survival	regulates	process	0.95
cell proliferation	promotes	process	0.95
cell survival	promotes	process	0.95
AKT	activates	protein	0.90
PI3K	activates	protein	0.90
cell differentiation	regulates	process	0.90
cancer	therapeutic_target	disease	0.90
EGFR Family	interacts_with	protein	0.88
ERK	upstream_of	protein	0.85
oxidative stress response	participates_in	pathway	0.80
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	causes	disease	0.65
Cancer	associated_with	disease	0.65
Aging	causes	disease	0.65
Alzheimer	causes	disease	0.65
Tumor	causes	disease	0.65
Als	causes	disease	0.65
Cancer	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	activates	disease	0.65
ALS	causes	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Als	activates	disease	0.65
Akt	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60

Incoming (143)

Source	Relation	Type	Str
trastuzumab	therapeutic_target	drug	0.90
pertuzumab	therapeutic_target	drug	0.90
EGFR	interacts_with	gene	0.80
PI3K	inhibits	gene	0.60
CANCER	therapeutic_target	gene	0.60
CDK4	therapeutic_target	gene	0.60
MTOR	inhibits	gene	0.60
AND	therapeutic_target	gene	0.60
AKT	inhibits	gene	0.60
EGFR	therapeutic_target	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
CANCER	expressed_in	gene	0.60
MTOR	therapeutic_target	gene	0.60
AND	expressed_in	gene	0.60
AKT	therapeutic_target	gene	0.60
ALZHEIMER	causes	gene	0.60
CANCER	associated_with	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
AXL	causes	gene	0.60
GAS6	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	causes	gene	0.60
AND	associated_with	gene	0.60
MICROGLIA	causes	gene	0.60
CANCER	biomarker_for	gene	0.60
RAS	expressed_in	gene	0.60
DNA	activates	gene	0.60
ERBB2	associated_with	gene	0.60
AND	biomarker_for	gene	0.60
PIK3CA	activates	gene	0.60
BAD	inhibits	gene	0.60
ERBB2	inhibits	gene	0.60
MITOPHAGY	associated_with	gene	0.60
AKT	activates	gene	0.60
PER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
CD8	activates	gene	0.60
GENES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CGAS	activates	gene	0.60
PD-L1	activates	gene	0.60
AKT	associated_with	gene	0.60
AMYLOID	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ERK	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
MEK	inhibits	gene	0.60
CANCER	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HER2

Understanding Entity Pages

Wiki Pages (16)

NICASTRIN Gene

Cyclin E2 (CCNE2) Protein

biocon

FC Gamma Receptor IIIA

Focused Ultrasound BBB Opening

Focused Ultrasound for Drug Delivery to Brain

EGFR — Epidermal Growth Factor Receptor

Cell Proliferation

CDC37 (Cell Division Cycle 37) Protein

GPER (G-Protein Coupled Estrogen Receptor) Neurons

WNT2 Gene

Roche

Yuan Zhang

CDC37