gene

WNT6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

WNT6 is a member of the Wnt family of signaling proteins that activates both canonical and non-canonical Wnt pathways, regulating neural crest cell migration, cortical neuron positioning, and oligodendrocyte differentiation.

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🧬 Gene Info

Gene Symbol	WNT6
Full Name	Wnt Family Member 6
Chromosome	2q35
Protein Type	Gene
Function	is a member of the Wnt family of secreted signaling proteins that plays essential roles in embryonic development, tissue patterning, and adult tissue homeostasis[@wntfamily2023].
Primary Expression	subventricular zone (neural stem cell niche), hippocampus (dentate gyrus), and cortex
Amino Acids	349 aa
Pathways	WNT, Wnt, wnt, Wnt Signaling
GeneCards	WNT6
Human Protein Atlas	WNT6
Signal peptide	Directs secretion from the cell
Wnt domain	Conserved cysteine-rich domain essential for receptor binding
Glycosylation sites	Post-translational modifications affecting protein stability
Lipid modification	Palmitoleoylation required for secretion and activity
Planar Cell Polarity (PCP)	Regulates cell polarity and migration
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WNT6 — Wnt Family Member 6

gene · 1090 words

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Pathway Diagram

graph TD
    WNT6["WNT6"]
    neurodegeneration["neurodegeneration"]
    WNT6 -->|"implicated_in"| neurodegeneration
    style WNT6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning WNT6 in their description or question text

No additional research found