gene

WNT9A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about WNT9A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

WNT9A is a Wnt signaling protein that activates canonical Wnt/β-catenin pathways, regulating nephron development, neural progenitor cell behavior, and showing altered expression in Alzheimer's disease.

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🧬 Gene Info

Gene Symbol	WNT9A
Full Name	Wnt Family Member 9A
Chromosome	1q42.13
Protein Type	Gene
Function	is a secreted signaling protein belonging to the Wnt family that plays essential roles in embryonic development, tissue patterning, and adult tissue homeostasis[@wntfamily2023].
Amino Acids	355 aa
Pathways	WNT, Wnt, wnt, Wnt pathway
GeneCards	WNT9A
Human Protein Atlas	WNT9A
Signal peptide	Directs secretion from producing cells
Wnt domain	Conserved cysteine-rich domain with 24 cysteine residues
Glycosylation sites	N-linked glycosylation affecting protein stability
Lipid modification	C-terminal palmitoleoylation required for secretion
Wnt/PCP pathway	Through FZD receptors without LRP
Wnt/Ca²⁺ pathway	Calcium release and PKC activation
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WNT9A — Wnt Family Member 9A

gene · 1206 words

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Pathway Diagram

graph TD
    WNT9A["WNT9A"]
    neurodegeneration["neurodegeneration"]
    WNT9A -->|"implicated_in"| neurodegeneration
    style WNT9A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning WNT9A in their description or question text

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