gene

XRCC7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XRCC7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

XRCC7 encodes DNA-PKcs, the catalytic subunit of DNA-PK essential for non-homologous end joining (NHEJ) and DNA repair in neurons

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🧬 Gene Info

Gene Symbol	XRCC7
Full Name	X-Ray Repair Cross-Complementing 7 / DNA-PK Catalytic Subunit
Aliases	DNA-PKcs
Chromosome	8q24.21
Function	is a central component of the non-homologous end joining (NHEJ) pathway, the predominant mechanism for repairing DNA double-strand breaks (DSBs) in mammalian cells.
Primary Expression	virtually all cell types:
Molecular Weight	469 kDa
Amino Acids	4128 aa
UniProt ID	P78527
NCBI Gene ID	5591
Ensembl ID	ENSG00000137413
OMIM	604743
GeneCards	XRCC7
Human Protein Atlas	XRCC7
Phosphorylation	Multiple serine/threonine sites
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: XRCC7 — AlphaFold P78527 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

XRCC7 (DNA-PKcs) - DNA-Dependent Protein Kinase Catalytic Subunit

gene · 1515 words

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XRCC7 Protein (DNA-PKcs)

protein · 536 words

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Pathway Diagram

graph TD
    XRCC7["XRCC7"]
    neurodegeneration["neurodegeneration"]
    XRCC7 -->|"implicated_in"| neurodegeneration
    style XRCC7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XRCC7 in their description or question text

No additional research found