gene

YWHAE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YWHAE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

2Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for YWHAE Gene

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🧬 Gene Info

Gene Symbol	YWHAE
Full Name	Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein Epsilon
Chromosome	17p13.3
Function	YWHAE encodes the 14-3-3 epsilon protein with essential neuronal functions
Molecular Weight	29 kDa
Pathways	MAPK, PI3K
UniProt ID	YWHAE
NCBI Gene ID	7531
Ensembl ID	ENSG00000100906
OMIM	609066
GeneCards	YWHAE
Human Protein Atlas	YWHAE
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

YWHAE Gene

gene · 514 words

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YWHAE Protein

protein · 1041 words

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Pathway Diagram

graph TD
    YWHAE["YWHAE Gene"]
    YWHAE_PROTEIN["14-3-3 Epsilon Protein"]
    SNCA["Alpha-Synuclein"]
    LRRK2["LRRK2 Kinase"]
    PROTEIN_AGGREGATION["Protein Aggregation"]
    LEWY_BODIES["Lewy Body Formation"]
    AUTOPHAGY["Autophagy Pathway"]
    MITOCHONDRIA["Mitochondrial Function"]
    KINASE_ACTIVITY["Kinase Activity"]
    NEUROINFLAMMATION["Neuroinflammation"]
    CELL_DEATH["Neuronal Cell Death"]
    PARKINSONS["Parkinson's Disease"]
    SYNAPTIC_FUNCTION["Synaptic Function"]
    PROTEIN_PHOSPHORYLATION["Protein Phosphorylation"]

    YWHAE -->|"encodes"| YWHAE_PROTEIN
    YWHAE_PROTEIN -->|"regulates"| SNCA
    YWHAE_PROTEIN -->|"regulates"| LRRK2
    YWHAE_PROTEIN -->|"modulates"| PROTEIN_PHOSPHORYLATION
    
    SNCA -->|"forms"| PROTEIN_AGGREGATION
    PROTEIN_AGGREGATION -->|"leads to"| LEWY_BODIES
    LEWY_BODIES -->|"promotes"| NEUROINFLAMMATION
    
    LRRK2 -->|"hyperactivation"| KINASE_ACTIVITY
    KINASE_ACTIVITY -->|"impairs"| AUTOPHAGY
    AUTOPHAGY -->|"dysfunction"| MITOCHONDRIA
    
    MITOCHONDRIA -->|"damage"| CELL_DEATH
    NEUROINFLAMMATION -->|"contributes to"| CELL_DEATH
    CELL_DEATH -->|"results in"| PARKINSONS
    
    YWHAE_PROTEIN -->|"maintains"| SYNAPTIC_FUNCTION
    SYNAPTIC_FUNCTION -->|"loss"| PARKINSONS

    style YWHAE fill:#1a3a4a,stroke:#4fc3f7
    style YWHAE_PROTEIN fill:#2a1a3a,stroke:#ce93d8
    style SNCA fill:#2a1a3a,stroke:#ce93d8
    style LRRK2 fill:#2a1a3a,stroke:#ce93d8
    style AUTOPHAGY fill:#1a3a2a,stroke:#81c784
    style SYNAPTIC_FUNCTION fill:#1a3a2a,stroke:#81c784
    style PROTEIN_AGGREGATION fill:#3a1a1a,stroke:#ef5350
    style LEWY_BODIES fill:#3a1a1a,stroke:#ef5350
    style NEUROINFLAMMATION fill:#3a1a1a,stroke:#ef5350
    style CELL_DEATH fill:#3a1a1a,stroke:#ef5350
    style PARKINSONS fill:#3a2a1a,stroke:#ffa726

Outgoing (2)

Target	Relation	Type	Str
SNCA	regulates	protein	0.70
LRRK2	regulates	protein	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning YWHAE in their description or question text

No additional research found