gene

ZFYVE26

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ZFYVE26: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ZFYVE26 (SPG15) gene encoding a protein involved in autophagy and endosomal trafficking

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🧬 Gene Info

Gene Symbol	ZFYVE26
Aliases	SPG15
Chromosome	14q24.3
Function	is a gene encoding a critical autophagy protein that plays essential roles in cellular protein homeostasis and organelle quality control.
Subcellular Localization	cytoplasmic membranes, particularly autophagosomes and late endosomes, where it serves as a scaffold for autophagy-relat
Molecular Weight	235 kDa
Amino Acids	100 aa
GeneCards	ZFYVE26
Human Protein Atlas	ZFYVE26
C-terminal Region	The C-terminal region contains multiple WD40 repeat-like sequences that facilitate interactions with various autophagy adaptors and regulatory proteins 7.
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ZFYVE26["ZFYVE26"]
    neurodegeneration["neurodegeneration"]
    ZFYVE26 -->|"implicated_in"| neurodegeneration
    style ZFYVE26 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning ZFYVE26 in their description or question text

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