gene

ZNF746

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZNF746: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

2Outgoing

3Incoming

Summary

Zinc Finger Protein 746 - Parkinson disease risk gene and transcriptional repressor of mitochondrial biogenesis

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🧬 Gene Info

Gene Symbol	ZNF746
Full Name	Zinc Finger Protein 746
Chromosome	7p12.1.
Protein Type	Transcription Factor
Function	is a transcription factor that functions as a transcriptional repressor, primarily targeting genes involved in mitochondrial biogenesis and oxidative stress response.
Molecular Weight	80 kDa
Amino Acids	724 aa
Exons	5
Pathways	NF-κB
UniProt ID	[Q8N2U4](https://www.uniprot.org/uniprot/Q8N2U4)
Ensembl ID	ENSG00000164684
OMIM	614629
GeneCards	ZNF746
Human Protein Atlas	ZNF746
Superoxide Dismutase (SOD1, SOD2)	ZNF746 represses SOD expression, affecting cellular antioxidant capacity
Associated Diseases	neurodegeneration
Interactions	c-Abl
KG Connections	5 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ZNF746["<b>ZNF746</b>"]
    c_Myc["c-Myc"]
    ZNF746 -->|"stabilizes"| c_Myc
    neurodegeneration["neurodegeneration"]
    ZNF746 -->|"implicated in"| neurodegeneration
    parkin["parkin"]
    parkin -->|"binds"| ZNF746
    c_Abl["c-Abl"]
    c_Abl -->|"phosphorylates"| ZNF746
    miR_101_3p["miR-101-3p"]
    miR_101_3p -->|"downregulates"| ZNF746
    style ZNF746 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (2)

Target	Relation	Type	Str
c-Myc	stabilizes	protein	0.80
neurons	expressed_in	cell_type	0.60

Incoming (3)

Source	Relation	Type	Str
parkin	binds	gene	0.90
c-Abl	phosphorylates	gene	0.90
miR-101-3p	downregulates	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ZNF746

Understanding Entity Pages

Summary

Wiki Pages (8)

ZNF746 Gene

PRKCD — Protein Kinase C Delta

Ubiquitin-Proteasome System Dysfunction in Alzheimer's Disease

Proteasomal Pathway in Neurodegeneration

Parkin (PRKN) Neurons

ZNF746 Protein