gene

C-MYC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C-MYC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

275Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet. View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	MYC
Full Name	MYC Proto-Oncogene, BHLH Transcription Factor
Aliases	c-Myc, bHLHe39
Chromosome	8q24.21
Function	Master transcription factor for cell proliferation. In neurodegeneration, reactivation linked to aberrant cell cycle re-entry.
Primary Expression	Ubiquitous; low in mature neurons
Molecular Weight	48.8 kDa
Gene Type	Protein-coding
Pathways	PI3K-AKT-mTOR, Wnt/beta-catenin, Cell cycle regulation
GeneCards	MYC
Human Protein Atlas	MYC
Associated Diseases	Pluripotency, Tumor
Interactions	Actin, AGING, AKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	267 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: C-MYC — AlphaFold P01106 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    C_MYC["C-MYC"] -->|"activates"| Pluripotency["Pluripotency"]
    C_MYC["C-MYC"] -->|"activates"| Carcinoma["Carcinoma"]
    C_MYC["C-MYC"] -->|"activates"| Cancer["Cancer"]
    C_MYC["C-MYC"] -->|"therapeutic target"| Tumor["Tumor"]
    C_MYC["C-MYC"] -->|"regulates"| Cancer_1["Cancer"]
    C_MYC["C-MYC"] -->|"activates"| Als["Als"]
    LDHA["LDHA"] -->|"activates"| C_MYC["C-MYC"]
    MYC["MYC"] -->|"activates"| C_MYC["C-MYC"]
    AND["AND"] -->|"activates"| C_MYC["C-MYC"]
    MYC_2["MYC"] -.->|"inhibits"| C_MYC["C-MYC"]
    style C_MYC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (186)

Target	Relation	Type	Str
Pluripotency	associated_with	phenotype	0.90
Pluripotency	activates	phenotype	0.90
Senescence	activates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	protects_against	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
Aging	regulates	disease	0.65
Glioblastoma	inhibits	disease	0.65
Ms	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Obesity	regulates	disease	0.65
Als	regulates	disease	0.65
Fibrosis	activates	disease	0.65
Cirrhosis	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
KAT2A	interacts_with	gene	0.60
YAP	activates	gene	0.60
MARK4	activates	gene	0.60
HIPPO	activates	gene	0.60
Tgf-Β	associated_with	pathway	0.60
AND	activates	gene	0.60
PP2A	activates	gene	0.60
CANCER	inhibits	gene	0.60
HNF4A	associated_with	gene	0.60

Incoming (89)

Source	Relation	Type	Str
RNA polymerase II	activates	protein	0.90
ZNF746	stabilizes	gene	0.80
AKT	regulates	gene	0.70
MTOR	regulates	gene	0.70
MTOR	enhances	gene	0.70
MTOR	enhances	gene	0.70
MTOR	regulates	gene	0.70
MYC	activates	gene	0.60
AND	activates	gene	0.60
MYC	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	inhibits	gene	0.60
SRC	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
DNA	interacts_with	gene	0.60
MYC	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
APP	activates	gene	0.60
RNA	activates	gene	0.60
LDHA	activates	gene	0.60
TRAF6	inhibits	gene	0.60
HDAC3	inhibits	gene	0.60
RNA	associated_with	gene	0.60
LNCRNA	associated_with	gene	0.60
CDKN2B-AS1	activates	gene	0.60
AKT1	activates	gene	0.60
AHR	regulates	gene	0.60
GASTRODIN	activates	gene	0.60
MYC	protects_against	gene	0.60
ALZHEIMER	activates	gene	0.60
LYSOSOME	regulates	gene	0.60
DRP1	regulates	gene	0.60
HMOX1	activates	gene	0.60
TFEB	regulates	gene	0.60
TFAM	activates	gene	0.60
CALCINEURIN	regulates	gene	0.60
NAD	activates	gene	0.60
NRF1	activates	gene	0.60
BNIP3	regulates	gene	0.60
SIRT1	activates	gene	0.60
MFN2	regulates	gene	0.60
MIEF2	regulates	gene	0.60
PINK1	regulates	gene	0.60
CANCER	regulates	gene	0.60
FXN	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
DNMT3A	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity