Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about alpha-synuclein oligomers: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| membrane permeabilization | causes | mechanism | 0.90 |
| neurotoxicity | causes | phenotype | 0.90 |
| Intracellular Aggregation | mediates | process | 0.90 |
| Microglia Activation | upregulates | process | 0.85 |
| Astrocytes | associated_with | cell_type | 0.80 |
| Astrocyte Damage | causes | phenotype | 0.75 |
| Peripheral Inflammation | interacts_with | process | 0.75 |
| neurotoxicity | causes | phenotype | 0.70 |
| templated seeding | activates | mechanism | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Glucosylceramide | enhances | drug | 0.90 |
| glucosylceramide | stabilizes | metabolite | 0.90 |
| biomarkers-alpha-synuclein-oligomers | describes | wiki | 0.90 |
| ASyn295 antibody | targets | drug | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.571
neurodegeneration | 2026-04-01 | 1 hypotheses Top: 0.525
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
Hypotheses and analyses mentioning alpha-synuclein oligomers in their description or question text
No additional research found