Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Glucosylceramide: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Gaucher disease | contributes_to | disease | 0.95 |
| alpha-synuclein oligomers | stabilizes | phenotype | 0.90 |
| alpha_synuclein | enhances | protein | 0.90 |
| Alpha-Synuclein Oligomers | enhances | protein | 0.90 |
| alpha_synuclein | causes | protein | 0.70 |
| GBA-alpha-synuclein bidirectional loop | causes | mechanism | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| glucocerebrosidase | regulates | protein | 0.90 |
| autophagy pathway | clears | pathway | 0.90 |
| UGCG | synthesizes | enzyme | 0.90 |
| eliglustat | inhibits | drug | 0.90 |
| glucosylceramide synthase | causes | enzyme | 0.90 |
| GBA | modulates | gene | 0.70 |
| UGCG | causes | gene | 0.70 |
| glucocerebrosidase | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Lysosomal GBA1 Enhancement via Glucosylceramide Reduction | 0.800 | neurodegeneration | Test |
| Glucosylceramide Accumulation from GCase Deficiency Disrupts | 0.700 | neurodegeneration | - |
| Glucosylceramide accumulation nucleates alpha-synuclein aggr | 0.525 | parkinsons | GBA-Synuclein Loop Therapeutics for PD |
| Glucosylceramide-mediated feedback loop drives GBA-synuclein | 0.380 | parkinsons | GBA-Synuclein Loop: Therapeutic Strategi |
| Selective Glucosylceramide Synthase Inhibition with Lysosoma | 0.000 | - | GBA-Synuclein Loop Therapeutics for PD |
Scientific analyses that reference this entity
molecular biology | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.525
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Pain has been frequently reported as an initial symptom and the most t | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
Hypotheses and analyses mentioning Glucosylceramide in their description or question text
No additional research found