cell_type

Astrocytes

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Astrocytes: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5678Connections

2Hypotheses

22Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	Astrocytes
Associated Diseases	ALZHEIMER'S, Alzheimer Disease
Related Genes	CHI3L1, BMAL1, APOE, RHOT1
Linked Hypotheses	52 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Pathway Diagram

graph TD
    Astrocytes["Astrocytes"] -->|"regulates"| NREM_Sleep["NREM Sleep"]
    style NREM_Sleep fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Astrocytes["Astrocytes"] -->|"modulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    style Synaptic_Plasticity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Astrocytes["Astrocytes"] -->|"expressed in"| CHI3L1["CHI3L1"]
    style CHI3L1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Astrocytes["Astrocytes"] -->|"involved in"| Fatty_Acid_Degradation["Fatty Acid Degradation"]
    style Fatty_Acid_Degradation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Astrocytes["Astrocytes"] -->|"expressed in"| BMAL1["BMAL1"]
    style BMAL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Astrocytes["Astrocytes"] -->|"associated"| Neuronal_Function["Neuronal Function"]
    style Neuronal_Function fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Astrocytes["Astrocytes"] -->|"involved in"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    style Blood_Brain_Barrier fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Connexin43["Connexin43"] -->|"expressed in"| Astrocytes["Astrocytes"]
    style Connexin43 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    YKL_40["YKL-40"] -->|"expressed in"| Astrocytes["Astrocytes"]
    style YKL_40 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CHI3L1_1["CHI3L1"] -->|"expressed in"| Astrocytes["Astrocytes"]
    style CHI3L1_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GFAP["GFAP"] -->|"biomarker for"| Astrocytes["Astrocytes"]
    style GFAP fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TNFR2["TNFR2"] -->|"expressed in"| Astrocytes["Astrocytes"]
    style TNFR2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style Astrocytes fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (3134)

Target	Relation	Type	Str
NREM Sleep	regulates	phenotype	0.95
Synaptic Plasticity	modulates	process	0.95
CHI3L1	expressed_in	protein	0.95
Fatty Acid Degradation	involved_in	process	0.95
BMAL1	expressed_in	gene	0.95
Neuronal Function	associated_with	process	0.95
Blood-Brain Barrier	involved_in	process	0.95
Neurons	associated_with	cell_type	0.95
APOE	expressed_in	protein	0.95
Tunnel Nanotube-Mediated Mitochondrial Transfer	mediates	process	0.95
RHOT1	expressed_in	gene	0.95
Neurovascular Unit	involved_in	brain_region	0.95
Metabolic Support	involved_in	process	0.95
Synapse Regulation	involved_in	process	0.95
Proteostasis	involved_in	process	0.95
Blood-Brain Barrier Maintenance	involved_in	process	0.95
Neuronal Activity	modulates	process	0.92
Neurodegeneration	contributes_to	process	0.90
Synapse Elimination	mediates	process	0.90
Neuroinflammation	mediates	process	0.90
Neuroinflammation	involved_in	process	0.90
Homeostasis	involved_in	process	0.90
Parkinson's Disease	involved_in	disease	0.90
BAG3	expressed_in	protein	0.90
Synapse Remodeling	regulates	process	0.90
Synaptic Transmission	modulates	process	0.90
Neurotransmitter Regulation	involved_in	process	0.90
Synaptic Plasticity	involved_in	process	0.90
Postoperative Cognitive Dysfunction	involved_in	disease	0.90
Alzheimer Disease	contributes_to	disease	0.90
Parkinson Disease	contributes_to	disease	0.90
Huntington Disease	contributes_to	disease	0.90
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.90
COMPLEMENT C3	product_of	protein	0.90
CCL2	product_of	protein	0.90
CCL5	product_of	protein	0.90
CXCL1	product_of	protein	0.90
Synaptic Transmission	regulates	process	0.90
GJA1	expressed_in	protein	0.90
Neuroinflammation	contributes_to	process	0.90
Kii ALS/PDC	contributes_to	disease	0.90
GSDMD	expressed_in	protein	0.90
Neuroprotection	mediates	phenotype	0.90
NEURON	promotes	cell_type	0.90
Neurotrophic Factors	expressed_in	protein	0.90
Cellular Senescence	involved_in	process	0.90
Kii Als/Pdc	contributes_to	disease	0.90
Cerebral Glucose Consumption	contributes_to	phenotype	0.90
Alzheimer'S Disease	contributes_to	disease	0.90
A1 Phenotype	associated_with	phenotype	0.90

Incoming (2544)

Source	Relation	Type	Str
Connexin43	expressed_in	protein	0.95
YKL-40	expressed_in	protein	0.95
CHI3L1	expressed_in	protein	0.95
GFAP	biomarker_for	protein	0.95
AMYLOID-BETA	associated_with	protein	0.95
CONNEXIN43	expressed_in	protein	0.95
GFAP	expressed_in	protein	0.95
RHOT1	expressed_in	gene	0.95
Aging	modulates	process	0.95
Channelrhodopsin-2	expressed_in	protein	0.92
Pink1-Mitophagy	expressed_in	pathway	0.92
Thyroid Hormone	targets	compound	0.90
APOE4	expressed_in	protein	0.90
C3	expressed_in	protein	0.90
AQP4	expressed_in	protein	0.90
GJA1	expressed_in	protein	0.90
CD38	expressed_in	protein	0.90
AQP4 Autoantibodies	activates	compound	0.90
LacCer	expressed_in	compound	0.90
Microglia	activates	cell_type	0.90
Outer Membrane Vesicles	interacts_with	compound	0.90
A1AR	expressed_in	receptor	0.90
Ros	activates	process	0.90
VEGFA	expressed_in	gene	0.90
IGG AUTOANTIBODY	targets	protein	0.90
Amyloid-Β	modulates	compound	0.90
Chr2	expressed_in	protein	0.90
Opto-A1Ar	expressed_in	protein	0.90
LCN2	expressed_in	protein	0.90
Pg OMVs	activates	compound	0.90
LRP1	expressed_in	gene	0.90
Decellularized Squid Mantle Scaffold	associated_with	compound	0.90
SQSTM1	expressed_in	gene	0.90
APOE4	regulates	gene	0.90
HB-EGF	expressed_in	protein	0.88
Optogenetics	modulates	process	0.88
116B	inhibits	compound	0.88
MALAT1	expressed_in	gene	0.85
Microglia	interacts_with	cell_type	0.85
SNCA	interacts_with	protein	0.85
Primary Cilia	expressed_in	cell_type	0.85
SNCA	activates	protein	0.85
Polystyrene Nanoplastics	activates	compound	0.85
C3-C3aR Signalling	mediates	pathway	0.85
P2Y1	expressed_in	receptor	0.85
P2Y2	expressed_in	receptor	0.85
APOE	expressed_in	protein	0.85
Oligonucleotide Transport Vehicle	expressed_in	drug	0.85
RIP3	regulates	protein	0.85
Sulfatide Deficiency	activates	phenotype	0.85

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
AMPK hypersensitivity in astrocytes creates enhanced mitocho	0.570	neurodegeneration	Mitochondrial transfer between astrocyte
Circadian Rhythm Entrainment of Reactive Astrocytes	0.481	neurodegeneration	Astrocyte reactivity subtypes in neurode

Mentioning Analyses (22)

Scientific analyses that reference this entity

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.596

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.610

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

molecular biology | 2026-04-13 | 0 hypotheses

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

cellular senescence | 2026-04-11 | 0 hypotheses

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

neurodegeneration | 2026-04-06 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168]	Ruan W, Li T, Bang IH, Lee J, Deng W, Ma	Nature	2025	1
Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923]	Fernandes M, Liguori C	Handb Clin Neurol	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504]	Hussain Y, Dar MI, Pan X	Metabolites	2024	1
Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017]	Zeng Y, Guo Z, Wu M, Chen F, Chen L	Cell Death Discov	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594]	Pan X, Mota S, Zhang B	Adv Exp Med Biol	2020	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuro [PMID:26121488]	Hang L, Thundyil J, Lim KL	Ann N Y Acad Sci	2015	1
AMPKα1 Deficiency in Macrophages Impairs Tendon Regeneration and Tendon Stem Cel [PMID:41694579]	Zhu L, Wang Y, Shi X, Yu M, Cai X, Chen	International journal of biolo	2026	0
Single-cell transcriptome analysis reveals a cellular immune response in common [PMID:41692207]	Shi X, Ji G, Liu D, Zhao T, Tian S, Li S	International journal of biolo	2026	0
Farrerol ameliorates hepatic insulin resistance via AMPKα1/mTOR/SREBP-1 pathway: [PMID:41702183]	Li Y, Feng X, Zheng L	Tissue & cell	2026	0
Integration proteomics analysis to identify AMPK as key target pathways of TCM f [PMID:41788172]	Chen YJ, Ning DS, Wang CC, Zhao HW, Wang	Journal of traditional and com	2026	0
Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoart [PMID:41791307]	Zhai Y, Zhou P, Dan L, Ma M, Liu B, Zhan	International immunopharmacolo	2026	0
Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011]	Wu L, Dong YT, Mu X, Luo X, Chen ZJ	The journal of prevention of A	2026	0
BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150]	Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa	Biochemistry and biophysics re	2026	0
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646]	Lin L, Liang X, Xu Z, Li Y, Guo Z et al.	Biomaterials	2026	0
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525]	Sica V, Sato T, Tsialtas I, Hernandez S,	J Biol Rhythms	2026	0
Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008]	Tsameret S, Froy O, Matz Y, Landau Z, Tw	Diabetologia	2026	0

Astrocytes

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Pathway Diagram

Outgoing (3134)

Incoming (2544)

Targeting Hypotheses (2)

Mentioning Analyses (22)

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

APOE4-driven lipid metabolism dysregulation in astrocytes and its role in AD

Senescent cell clearance as neurodegeneration therapy

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Which cell types show the most significant expression changes for neurodegenerat

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Extracellular vesicle biomarkers for early AD detection

Mitochondrial transfer between astrocytes and neurons

Senolytic therapy for age-related neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Mitochondrial transfer between astrocytes and neurons

Related Papers (20)

Astrocytes

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

Atypical Parkinsonism

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Pathway Diagram

Outgoing (3134)

Incoming (2544)

Targeting Hypotheses (2)

Mentioning Analyses (22)

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

APOE4-driven lipid metabolism dysregulation in astrocytes and its role in AD

Senescent cell clearance as neurodegeneration therapy

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Which cell types show the most significant expression changes for neurodegenerat

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Extracellular vesicle biomarkers for early AD detection

Mitochondrial transfer between astrocytes and neurons

Senolytic therapy for age-related neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Mitochondrial transfer between astrocytes and neurons

Related Papers (20)