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Ono Pharmaceutical

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Related Hypotheses (13)

Microbial Inflammasome Priming Prevention
Score: 0.65Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE-TREM2 Interaction Modulation
Score: 0.74TREM2-Dependent Microglial Senescence Transition
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-mediated microglial tau clearance enhancement
Score: 0.62Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69LRP1-Dependent Tau Uptake Disruption
Score: 0.60Extracellular Vesicle Biogenesis Modulation
Score: 0.58Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57

Related Analyses (5)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSynaptic pruning by microglia in early AD
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (5 edges)

Ononin treats Triple-Negative Breast Cancer
Ononin inhibits Lung Metastasis
Ononin inhibits Cell Invasiveness
Ononin inhibits Epithelial-Mesenchymal Transition
Ononin associated_with Apoptosis

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