Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about dU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| HNRNPD | binds | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plant-based dietary patterns and Alzheimer's disease risk in multiethn | clinical | Alzheimer's disease and relate | 0.950 | 0.00 | human patients | proposed | N/A |
| GPR109A receptor validation using knockout macrophages | exploratory | Mycoplasma pneumoniae pneumoni | 0.920 | 0.00 | GPR109A knockout mouse macroph | proposed | N/A |
| CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co | clinical | Alzheimer's Disease | 0.900 | 0.50 | aortic endothelial cells | proposed | $6,550,000 |
| Periodontitis-induced colonic inflammation in mice | validation | Periodontitis and intestinal i | 0.900 | 0.00 | C57BL/6J mice | proposed | N/A |
| Fecal microbiota transplantation from periodontitis donors | validation | Periodontitis-associated gut d | 0.900 | 0.00 | Germ-free mice with fecal micr | proposed | N/A |
| GPR109A functional modulation with pharmacological agents | validation | Periodontitis with intestinal | 0.880 | 0.00 | C57BL/6J mice with ligature-in | proposed | N/A |
| Probiotic CBM588 supplementation rescue experiment | validation | Periodontitis-associated intes | 0.850 | 0.00 | C57BL/6J mice with periodontit | proposed | N/A |
| s:** - Test tau spreading in AQP4 knockout vs wild-type mice with PSP/ | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $260,000 |
| Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,900,000 |
| DLB Cognitive Fluctuation Mechanism Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| NPH Glymphatic System Interaction Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Circadian Dysfunction as Driver of Neurodegeneration | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep Disruption and Alzheimer's Disease — mechanism and intervention | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Respiratory Network Interaction in ALS — Experiment Design | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868] | Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X | Pharmacol Rep | 2025 | 1 |
| Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662] | Dashti HS, Daghlas I, Lane JM, Huang Y, | Nat Commun | 2021 | 1 |
| Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813] | Sun Y, Tisdale RK, Kilduff TS | Front Neurol Neurosci | 2021 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| GPR109a-AMPK axis mediates the Attenuation of uric acid-induced M1 macrophage po [PMID:41882026] | Du M, He Y, Zhu Y, Chen W, Chen X, Yang | Scientific reports | 2026 | 0 |
| Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppres [PMID:41638192] | Ding N, Wu H, Hua Y, Hua R, Li B, Xie Y, | Cell metabolism | 2026 | 0 |
| Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840] | Tortelote GG | Pediatr Nephrol | 2026 | 0 |
| Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of [PMID:41422555] | Mishra AK, Jain S | ACS Chem Neurosci | 2026 | 0 |
| The association of Alzheimer's disease-related SNPs with mild cognitive impairme [PMID:41606232] | Xie Z, Tu W, Ye XF, Hua L, Zhang X et al | Sci Rep | 2026 | 0 |
| Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452] | Akkaoui J, Devadoss D, Rodriguez MD, Ari | Neural Regen Res | 2026 | 0 |
| Genetic Burden and <i>APOE</i> Methylation in a Korean Multi-Generational Alzhei [PMID:41745359] | Eom Je-Hyun; Cho Mu-Yeol; Kim Ji-Won; Ki | Journal of personalized medici | 2026 | 0 |
| Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052] | Burdman Gabriel; Akkaoui Juliet; Colon N | Neurology international | 2026 | 0 |
| Posttraumatic stress disorder is associated with Alzheimer's disease-relevant mo [PMID:41960318] | Seijo MA, Yohannes PA, Rogers AL, Gonzal | Res Sq | 2026 | 0 |
| Xin-Jia-Tong-Xie-Yao-Fang restores the intestinal barrier to alleviate irritable [PMID:41655800] | Zhu J, Yang L, Fang Z, Chen J, Fu R, Liu | Microbial pathogenesis | 2026 | 0 |
| Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452] | Akkaoui J, Devadoss D, Rodriguez MD, Ari | Neural regeneration research | 2026 | 0 |
| Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408] | Cattero V, Mayer T, Veilleux A, Roussel | Scientific reports | 2026 | 0 |
| Qingfei Tongluo Jiedu Formula Regulates M2 Macrophage Polarization via the Butyr [PMID:41754753] | Liu Z, Fan Q, Sun R, Jiang Y | Pharmaceuticals (Basel, Switze | 2026 | 0 |
| Periodontitis promotes intestinal inflammation through gut microbiota-mediated s [PMID:41816355] | Wang X, Xu Z, Yao Y, Jia H, Du M, Wang S | Frontiers in cellular and infe | 2026 | 0 |
| Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052] | ["Burdman G", "Akkaoui J", "Colon N", "P | Neurology international | 2026 | 0 |
| Hydroxycarboxylic acid receptor 2 (GPR109A) and retinopathies: pathways and pros [PMID:41889514] | Lester J, Amamoo R, Thounaojam MC, Marti | Frontiers in medicine | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning dU in their description or question text
Score: 0.840 · protein-biochemistry · 2026-04-21
## **Molecular Mechanism and Rationale** The recognition of amyloidogenic protein species by the heat shock protein 70
Score: 0.819 · neurodegeneration · 2026-04-28
This hypothesis proposes that CYP46A1 overexpression gene therapy prevents neurodegeneration by disrupting the pathologi
Score: 0.814 · neurodegeneration · 2026-04-16
## Mechanistic Overview Extracellular Vesicle Biogenesis Modulation starts from the claim that modulating CHMP4B within
Score: 0.811 · neurodegeneration · 2026-04-16
## Mechanistic Overview CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds sta
Score: 0.805 · neurodegeneration · 2026-04-02
## Mechanistic Overview Targeted Butyrate Supplementation for Microglial Phenotype Modulation starts from the claim that
Score: 0.802 · lipidomics · 2026-04-25
The hypothesis proposes that ω-3 docosahexaenoic acid (DHA) is metabolized by CYP2J2 to generate protective epoxides tha
Score: 0.800 · neurodegeneration · 2026-05-04
GBA1 mutations increase α-synuclein aggregation risk through glucosylceramide accumulation. Enhancement of GCase activit
Score: 0.789 · neurodegeneration · 2026-04-02
## Mechanistic Overview Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming starts from the claim
Score: 0.782 · neurodegeneration · 2026-04-02
## Mechanistic Overview Selective Acid Sphingomyelinase Modulation Therapy starts from the claim that modulating SMPD1 w
Score: 0.780 · neurodegeneration · 2026-04-22
## Mechanistic Overview Sleep-Dependent Glymphatic Clearance Expands the Therapeutic Window by Reducing Extracellular Ta
Score: 0.778 · neurodegeneration · 2026-04-16
## Mechanistic Overview SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resiliency Against Microbiome-Induced Neu
Score: 0.774 · neuroscience · 2026-04-07
## Mechanistic Overview Dual-Circuit Tau Vulnerability Cascade starts from the claim that modulating MAPT within the dis
Score: 0.774 · neuroscience · 2026-04-04
## Mechanistic Overview Thalamocortical Synchrony Restoration via NMDA Modulation starts from the claim that modulating
Score: 0.773 · neurodegeneration · 2026-04-02
## Mechanistic Overview Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modulation starts from the claim that mo