Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HNRNPD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HNRNPD is a gene implicated in neurodegeneration research. Key relationships include: expressed in, interacts with, upregulates. Connected to 18 entities in the SciDEX knowledge graph.
| Gene Symbol | HNRNPD |
| Full Name | HNRNPD |
| Chromosome | 4q21.22 |
| Protein Type | Gene |
| Function | The HNRNPD gene encodes heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0), also known as AUF1. |
| Primary Expression | neurons throughout the brain - High expression in cerebral cortex - Present in both excitatory and inhib |
| NCBI Gene ID | Search NCBI |
| GeneCards | HNRNPD |
| Human Protein Atlas | HNRNPD |
| Associated Diseases | neurodegeneration |
| Interactions | ZHX2, NPM-ALK |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
HNRNPD["<b>HNRNPD</b>"]
ZHX2["ZHX2"]
HNRNPD -->|"interacts with"| ZHX2
SERPINA3["SERPINA3"]
HNRNPD -->|"stabilizes"| SERPINA3
DNA_end_resection["DNA-end resection"]
HNRNPD -->|"inhibits"| DNA_end_resection
dU["dU"]
HNRNPD -->|"binds"| dU
dU_repair["dU repair"]
HNRNPD -->|"regulates"| dU_repair
FOXM1["FOXM1"]
HNRNPD -->|"upregulates"| FOXM1
PI3K["PI3K"]
HNRNPD -->|"expressed in"| PI3K
HSP90B1["HSP90B1"]
HNRNPD -->|"expressed in"| HSP90B1
DDX5["DDX5"]
HNRNPD -->|"expressed in"| DDX5
SOD2["SOD2"]
HNRNPD -->|"expressed in"| SOD2
AKT["AKT"]
HNRNPD -->|"expressed in"| AKT
VEGFA["VEGFA"]
HNRNPD -->|"expressed in"| VEGFA
THOR["THOR"]
THOR -->|"interacts with"| HNRNPD
NPM_ALK["NPM-ALK"]
NPM_ALK -->|"interacts with"| HNRNPD
circSTX6["circSTX6"]
circSTX6 -->|"interacts with"| HNRNPD
style HNRNPD fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ZHX2 | interacts_with | protein | 0.80 |
| SERPINA3 | stabilizes | gene | 0.80 |
| DNA-end resection | inhibits | biological_process | 0.80 |
| dU | binds | chemical | 0.80 |
| dU repair | regulates | biological_process | 0.80 |
| FOXM1 | upregulates | gene | 0.80 |
| PI3K | expressed_in | gene | 0.60 |
| HSP90B1 | expressed_in | gene | 0.60 |
| DDX5 | expressed_in | gene | 0.60 |
| SOD2 | expressed_in | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| VEGFA | expressed_in | gene | 0.60 |
| Akt | expressed_in | pathway | 0.60 |
| Pi3K | expressed_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||