Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about disease_associated_microglia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | promotes | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro | 0.662 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri | 0.515 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| Disease-Associated Microglia Metabolic Reprogramming | 0.502 | neurodegeneration | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop | 0.493 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub | 0.491 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul | 0.485 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-06 | 0 hypotheses
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.486
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445] | Qin J, Ma S, Wang J, Huang S, Luan J, He | Cell death & disease | 2026 | 0 |
| Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795] | Gao C, Liu B, Zhang R, Tian J, Xin H | Toxicology mechanisms and meth | 2026 | 0 |
| NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890] | Rao W, Huang Y, Li J, Chen Q, Sun J et a | J Stroke Cerebrovasc Dis | 2026 | 0 |
| Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892] | Lin D, Li K, Kuang W, Chen Z, Zhang M | World J Mens Health | 2026 | 0 |
| Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496] | Che L, Zhu L, Zhou L, Zhou Y | Biochim Biophys Acta Rev Cance | 2026 | 0 |
| B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570] | Chien Y, Xia R, Zhou D, Ai Y, Wu L et al | Hepatol Commun | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558] | Singh P, Rath SL | Journal of Alzheimer's disease | 2026 | 0 |
| Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334] | Song C, Wu X, Chen C, Shen B, He Y, Liu | Drug design, development and t | 2026 | 0 |
| Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914] | ["Xin R", "Zhang J", "Zhang Y", "Dai M", | Free radical biology & medicin | 2026 | 0 |
| Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086] | Wang Y, Zhang W, Zhang M, Zhu Y, Wang W, | Tissue & cell | 2026 | 0 |
| Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362] | Xu J, Sun M, Wang C, Ju P, Guan XD, Xie | International journal of ophth | 2026 | 0 |
| Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates. [PMID:41819088] | Liu L, Zheng Z, You W, Yang P, Wen Y et | Cell Metab | 2026 | 0 |
| LPCAT3 deficiency Drives phospholipid remodeling and mitochondrial oxidative dys [PMID:41951050] | Shao G, Ye C, Sun C, Pan J, Lu L et al. | J Adv Res | 2026 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | Neuroscientist | 2025 | 0 |
| Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Am [PMID:40442550] | Wongjaikam S, Siengdee P, Somnus A, Govi | Neurotoxicity research | 2025 | 0 |
| Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzhei [PMID:40640358] | Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhan | Scientific reports | 2025 | 0 |
| Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathol [PMID:39510074] | ["Zha Xu", "Liu Xicheng", "Wei Mengping" | Cell metabolism | 2025 | 0 |
| Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis [PMID:41394684] | Montesinos J, Yun TD, Salomón-Cruz ID, A | bioRxiv : the preprint server | 2025 | 0 |
| Danggui Shaoyao San ameliorates Alzheimer's disease by regulating lipid metaboli [PMID:40271063] | Gong K, Zhou S, Xiao L, Xu M, Zhou Y, Lu | Frontiers in pharmacology | 2025 | 0 |