Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about disease_associated_microglia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-06 | 7 hypotheses
neurodegeneration | 2026-04-04 | 20 hypotheses Top: 0.651
neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.774
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.886
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice | validation | Alzheimer's disease | 0.900 | 0.00 | 5xFAD transgenic mice | proposed | N/A |
| Transcriptomic profiling and differential expression analysis | exploratory | Alzheimer's disease | 0.900 | 0.00 | 1-month-old APP/PS1 mice cereb | proposed | N/A |
| bEV isolation and LPS quantification from human samples | clinical | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445] | Qin J, Ma S, Wang J, Huang S, Luan J, He | Cell death & disease | 2026 | 0 |
| Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795] | Gao C, Liu B, Zhang R, Tian J, Xin H | Toxicology mechanisms and meth | 2026 | 0 |
| NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890] | Rao W, Huang Y, Li J, Chen Q, Sun J et a | J Stroke Cerebrovasc Dis | 2026 | 0 |
| Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892] | Lin D, Li K, Kuang W, Chen Z, Zhang M | World J Mens Health | 2026 | 0 |
| Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496] | Che L, Zhu L, Zhou L, Zhou Y | Biochim Biophys Acta Rev Cance | 2026 | 0 |
| B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570] | Chien Y, Xia R, Zhou D, Ai Y, Wu L et al | Hepatol Commun | 2026 | 0 |
| Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558] | Singh P, Rath SL | Journal of Alzheimer's disease | 2026 | 0 |
| Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334] | Song C, Wu X, Chen C, Shen B, He Y, Liu | Drug design, development and t | 2026 | 0 |
| Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914] | ["Xin R", "Zhang J", "Zhang Y", "Dai M", | Free radical biology & medicin | 2026 | 0 |
| Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086] | Wang Y, Zhang W, Zhang M, Zhu Y, Wang W, | Tissue & cell | 2026 | 0 |
| Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362] | Xu J, Sun M, Wang C, Ju P, Guan XD, Xie | International journal of ophth | 2026 | 0 |
| Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Am [PMID:40442550] | Wongjaikam S, Siengdee P, Somnus A, Govi | Neurotoxicity research | 2025 | 0 |
| Acyl-CoA synthetase long-chain family member 4-A novel prognostic marker in cuta [PMID:41918944] | Paria S, Lapides R, Saravi B, Rajagopal | Frontiers in medicine | 2025 | 0 |
| Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzhei [PMID:40640358] | Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhan | Scientific reports | 2025 | 0 |
| Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathol [PMID:39510074] | ["Zha Xu", "Liu Xicheng", "Wei Mengping" | Cell metabolism | 2025 | 0 |
| Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis [PMID:41394684] | Montesinos J, Yun TD, Salomón-Cruz ID, A | bioRxiv : the preprint server | 2025 | 0 |
| Danggui Shaoyao San ameliorates Alzheimer's disease by regulating lipid metaboli [PMID:40271063] | Gong K, Zhou S, Xiao L, Xu M, Zhou Y, Lu | Frontiers in pharmacology | 2025 | 0 |
| Single-cell spatial transcriptomics reveals distinct patterns of dysregulation i [PMID:39103533] | Johnston KG, Berackey BT, Tran KM, Gelbe | Molecular psychiatry | 2025 | 0 |
| Deferiprone in Alzheimer Disease: A Randomized Clinical Trial. [PMID:39495531] | Ayton S, Barton D, Brew B, Brodtmann A, | JAMA neurology | 2025 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.86 · 2026-04-12
closed · Rounds: 5 · Score: 0.95 · 2026-04-12
closed · Rounds: 4 · Score: 0.93 · 2026-04-06
closed · Rounds: 4 · Score: 0.89 · 2026-04-02
closed · Rounds: 4 · Score: 0.57 · 2026-04-01
Hypotheses and analyses mentioning disease_associated_microglia in their description or question text
Score: 0.700 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) functions as a criti
Score: 0.631 · neurodegeneration · 2026-04-12
## Mechanistic Overview Disease-Associated Microglia Metabolic Reprogramming starts from the claim that modulating TREM2
Score: 0.571 · neuroinflammation · 2026-04-21
## Mechanistic Overview Disease-Associated Microglia (DAM) Program Drives IBA1 Downregulation starts from the claim that
Score: 0.459 · alzheimers · 2026-04-26
ACSL4 (acyl-CoA synthetase long-chain family member 4) drives neuroinflammatory amplification in disease-associated micr
Score: 0.403 · alzheimers · 2026-04-26
Somatostatin-positive interneurons in entorhinal cortex layer II serve dual roles as gamma frequency gatekeepers and mic
Score: 0.000 · unknown disease · 2026-04-28
Selective HDAC modulators or DNA methyltransferase inhibitors to epigenetically silence SPP1 expression in activated mic