Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PLD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PLD4 |
| Function | encodes a member of the phospholipase D family that possesses both phospholipase D enzymatic activity and 5'→3' exonuclease capability. |
| Ensembl ID | ENSG00000138184 |
| GeneCards | PLD4 |
| Human Protein Atlas | PLD4 |
| N-terminal Region | Contains a predicted signal peptide and extracellular domain for secreted or membrane-associated forms |
| Catalytic Domain | Features the characteristic HKD motifs (HKD: histidine-lysine-aspartate) essential for catalytic activity, though PLD4 shows variations in these motifs |
| C-terminal Region | Includes potential regulatory elements and protein-protein interaction motifs |
| Microglia | The resident brain macrophages |
| Oligodendrocyte Precursor Cells (OPCs) | Progenitor cells for myelinating oligodendrocytes |
| Perivascular Macrophages | Macrophages associated with blood vessels |
| Lipid Hydrolysis | PLD4 can hydrolyze phospholipids within lysosomal membranes, generating lipid products that influence membrane curvature and fusion events |
| Membrane Trafficking | The enzyme regulates endosomal maturation and lysosomal fusion processes through lipid modification |
| Lysosomal pH Maintenance | PLD4 activity influences proton pump function and lysosomal acidification |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PLD4["PLD4"]
neurodegeneration["neurodegeneration"]
PLD4 -->|"implicated_in"| neurodegeneration
style PLD4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PLD4 in their description or question text
No additional research found