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Home / Wiki / Entity: PLD4 (Phospholipase D Family Member 4)

entity 2,727 words KG: PLD4 2026-03-27

kind:entity section:entities state:published phospholipase microglia autophagy neuroinflammation

Contents

PLD4 (Phospholipase D Family Member 4)

Knowledge Graph

Related Hypotheses (17)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69 APOE-Dependent Autophagy Restoration
Score: 0.61 Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59 Microbial Inflammasome Priming Prevention
Score: 0.58 Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54 Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53 Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52 Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51 TREM2-mediated microglial tau clearance enhancement
Score: 0.49 APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.49 APOE-TREM2 Interaction Modulation
Score: 0.48 APOE Isoform Expression Across Glial Subtypes
Score: 0.48 Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46 APOE Isoform Conversion Therapy
Score: 0.44 TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.43 TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (28)

TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed 4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived Synaptic pruning by microglia in early AD
neurodegeneration · archived Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · archived Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived Gene expression changes in aging mouse brain predicting neur
neurodegeneration · failed Gene expression changes in aging mouse brain predicting neur
neurodegeneration · failed Gene expression changes in aging mouse brain predicting neur
neurodegeneration · failed Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived Extracellular vesicle biomarkers for early AD detection
neurodegeneration · completed Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (3)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40 CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40 Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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