Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about epigenetic clock: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Partial Reprogramming | associated_with | process | 0.88 |
| NAD+ precursors | modulates | drug | 0.70 |
| SIRT1 | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| PD genetic aging variants accelerating cell-type-specific ep | 0.626 | neurodegeneration | Genetic Aging Landscape Variants and Epi |
| TDP-43 Pathology Creates a Distinct Epigenetic Clock "Signat | 0.387 | - | Epigenetic clocks as biomarkers for Alzh |
| Ethnic and Metabolic Epigenetic Clock Divergence Explains Di | 0.376 | - | Epigenetic clocks as biomarkers for Alzh |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.345
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.779
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of [PMID:40157356] | Rummens Jens; Khalil Bilal; Yıld&# | Neuron | 2025 | 0 |
| TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of [PMID:40157356] | ["Rummens Jens", "Khalil Bilal", "Y\u013 | Neuron | 2025 | 0 |
| The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not [PMID:38079474] | Zibold, Lessard, Picard, da Silva, Zador | Brain : a journal of neurology | 2024 | 0 |
| Epigenetic/circadian clocks and PCOS. [PMID:38600622] | Vatier C, Christin-Maitre S | Hum Reprod | 2024 | 0 |
| The role of cellular senescence in neurodegenerative diseases. [PMID:38744709] | Wang Y, Kuca K, You L, Nepovimova E, Heg | Archives of toxicology | 2024 | 0 |
| TDP-43 nuclear condensation and neurodegenerative proteinopathies. [PMID:39327159] | Vassallu, Igaz | Trends in neurosciences | 2024 | 0 |
| TDP-43 nuclear condensation and neurodegenerative proteinopathies. [PMID:39327159] | Unknown | Trends in neurosciences | 2024 | 0 |
| The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not [PMID:38079474] | Unknown | Brain : a journal of neurology | 2024 | 0 |
| The role of cellular senescence in neurodegenerative diseases. [PMID:38744709] | Wang Y, Kuca K, You L, Nepovimova E, Heg | Archives of toxicology | 2024 | 0 |
| Exercise therapy to prevent and treat Alzheimer's disease. [PMID:37600508] | ["Pahlavani H"] | Frontiers in aging neuroscienc | 2023 | 0 |
| Exercise therapy to prevent and treat Alzheimer's disease. [PMID:37600508] | ["Pahlavani H"] | Frontiers in aging neuroscienc | 2023 | 0 |
| Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. [PMID:34239348] | Zhang, Wei, Zhao, Ma, Jiang et al. | International journal of biolo | 2022 | 0 |
| Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and ag [PMID:35112738] | Gruijs da Silva LA, Simonetti F, Hutten | The EMBO journal | 2022 | 0 |
| Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive dec [PMID:35130907] | ["Liu Sen", "Fan Min", "Xu Jing-Xian", " | Journal of neuroinflammation | 2022 | 0 |
| Metabolic programs tailor T cell immunity in viral infection, cancer, and aging. [PMID:35235773] | Møller SH, Hsueh PC, Yu YR | Cell Metab | 2022 | 0 |
| Epigenetic clock: A promising biomarker and practical tool in aging. [PMID:36206857] | Duan R, Fu Q, Sun Y | Ageing Res Rev | 2022 | 0 |
| DNA methylation GrimAge version 2. [PMID:36516495] | Lu AT, Binder AM, Zhang J | Aging (Albany NY) | 2022 | 0 |
| Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. [PMID:34239348] | Unknown | International journal of biolo | 2022 | 0 |
| Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive dec [PMID:35130907] | ["Liu Sen", "Fan Min", "Xu Jing-Xian", " | Journal of neuroinflammation | 2022 | 0 |
| Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and ag [PMID:35112738] | Gruijs da Silva LA, Simonetti F, Hutten | The EMBO journal | 2022 | 0 |
Multi-agent debates referencing this entity
active · Rounds: 4 · Score: 0.67 · 2026-04-28
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.88 · 2026-04-01
Hypotheses and analyses mentioning epigenetic clock in their description or question text
No additional research found