Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ferroptotic vulnerability: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| LPCAT3 | causes | gene | 0.90 |
| Iron accumulation | risk_factor_for | process | 0.70 |
| Oxidative stress | risk_factor_for | process | 0.70 |
| Glutathione depletion | risk_factor_for | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul | 0.764 | alzheimers | Cell type vulnerability in Alzheimers Di |
| IRP2-Iron Axis Modulation to Reduce Ferroptotic Vulnerabilit | 0.398 | neurodegeneration | Microglial subtypes in neurodegeneration |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.891
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| bEV isolation and LPS quantification from human samples | clinical | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in [PMID:38412923] | ["Zhang Tian-Ci", "Lin Yi-Can", "Sun Nin | Neurochemistry international | 2024 | 0 |
| Ferroptosis Signaling Pathways: Alzheimer's Disease. [PMID:37257500] | Unknown | 2023 | 0 | |
| A Bioinformatics Perspective on the Dysregulation of Ferroptosis and Ferroptosis [PMID:36438927] | Unknown | 2022 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 0.90 · 2026-04-03
Hypotheses and analyses mentioning ferroptotic vulnerability in their description or question text
No additional research found