phenotype

oxidative stress

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about oxidative stress: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9849Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

oxidative stress is a phenotype associated with neurodegeneration research. Key relationships include: activates, causes, protects against. Associated with Alzheimer's disease, Down syndrome, Parkinson's disease. Connected to 107 entities in the SciDEX knowledge graph.

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Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    oxidative_stress["oxidative stress"] -->|"activates"| NRF2["NRF2"]
    oxidative_stress["oxidative stress"] -->|"causes"| mitochondrial_fragmentation["mitochondrial fragmentation"]
    oxidative_stress["oxidative stress"] -->|"causes"| autophagy["autophagy"]
    oxidative_stress["oxidative stress"] -->|"activates"| mitophagy["mitophagy"]
    oxidative_stress["oxidative stress"] -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    oxidative_stress["oxidative stress"] -->|"contributes to"| GSK3B["GSK3B"]
    CYP2E1["CYP2E1"] -->|"causes"| oxidative_stress["oxidative stress"]
    NRF2_1["NRF2"] -->|"protects against"| oxidative_stress["oxidative stress"]
    hesperetin["hesperetin"] -.->|"inhibits"| oxidative_stress["oxidative stress"]
    AMBRA1["AMBRA1"] -->|"causes"| oxidative_stress["oxidative stress"]
    style oxidative_stress fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (3857)

Target	Relation	Type	Str
TDP-43 aggregation	promotes	process	1.00
NRF2	activates	protein	0.90
mitochondrial fragmentation	causes	phenotype	0.90
autophagy	causes	pathway	0.90
ischemic stroke	contributes_to	disease	0.90
STING/YAP activation	activates	process	0.90
hepatocyte injury	causes	process	0.90
mitochondrial respiration	increases	process	0.90
mitochondrial DNA	damages	compound	0.90
neurodegenerative disorders	drives	disease	0.90
MTDNA	causes	gene	0.90
neuronal damage	causes	phenotype	0.90
neurodegeneration	drives	process	0.90
endothelial dysfunction	drives	phenotype	0.90
TRIM21 enrichment	promotes	phenotype	0.88
granulosa cell apoptosis	promotes	process	0.88
neuroinflammation	contributes_to	process	0.88
mitophagy	activates	pathway	0.85
TMX2	regulates	protein	0.85
NLRP3	activates	protein	0.85
P53	regulates	gene	0.85
TMX2	upregulates	protein	0.85
neurodegeneration	promotes	process	0.85
sarcopenia	contributes_to	phenotype	0.85
microtubule disintegration	promotes	process	0.85
neurodegeneration	contributes_to	disease	0.85
dopaminergic neurons	contributes_to	cell_type	0.85
programmed cell death	associated_with	process	0.85
retinal pigment epithelium	damages	cell_type	0.82
cardiac regeneration	inhibits	process	0.82
neuronal cell death	causes	phenotype	0.80
Alzheimer's disease	causes	disease	0.80
GSK3B	contributes_to	gene	0.80
PP2A	inhibits	protein	0.80
senescence	promotes	process	0.80
Aβ	elevates	protein	0.80
neurofibrillary tangles	elevates	protein	0.80
neuronal death	causes	process	0.80
insulin production	impairs	process	0.80
insulin resistance	increases	process	0.80
INFLAMMATION	induces	process	0.80
TDP-43 aggregation	causes	process	0.80
TUMOR	promotes	disease	0.80
retinal toxicity	causes	disease	0.80
behavioral disorders	contributes_to	phenotype	0.80
Alzheimer's Disease	contributes_to	disease	0.80
ERK1/2	regulates	protein	0.75
NLRP3	upstream_of	protein	0.75
neuronal cell death	drives	process	0.75
motor neurons degeneration	activates	process	0.70

Incoming (5992)

Source	Relation	Type	Str
ferritinophagy	promotes	process	0.95
B.glomerulata	inhibits	drug	0.95
1800 MHz radiofrequency radiation	causes	compound	0.95
iron	mediates	compound	0.95
ACOD1	inhibits	gene	0.94
CYP2E1	causes	protein	0.90
NRF2	protects_against	protein	0.90
hesperetin	inhibits	drug	0.90
AMBRA1	causes	protein	0.90
impaired mitophagy	promotes	process	0.90
oxygen-glucose deprivation/reoxygenation	associated_with	process	0.90
SLC15A3	promotes	protein	0.90
PDE4D overexpression	promotes	gene	0.90
Polyphyllin B	inhibits	drug	0.90
SOD1	promotes	protein	0.90
B.glomerulata	prevents	drug	0.90
antioxidant enzymes	protects_against	process	0.90
rotenone	causes	compound	0.90
mitochondrial dysfunction	drives	process	0.90
SOD	suppresses	protein	0.90
neuroinflammation	causes	process	0.90
sleep deprivation	causes	phenotype	0.90
tert-Butyl hydroperoxide	associated_with	compound	0.90
PM10	causes	compound	0.90
ALOX15	mediates	gene	0.90
Metformin	associated_with	drug	0.90
lead	promotes	compound	0.90
mercury	promotes	compound	0.90
Palmitic acid	associated_with	compound	0.90
mitochondrial dysfunction	promotes	process	0.90
AKT	modulates	protein	0.88
impaired protein clearance	promotes	process	0.88
AMPK	prevents	protein	0.88
MAPK	promotes	pathway	0.88
amyloid-beta	causes	protein	0.88
Tardbp	involved_in	protein	0.88
PINK1	inhibits	gene	0.85
metabolic dysregulation	promotes	process	0.85
TMZ	associated_with	drug	0.85
redox homeostasis	suppresses	process	0.85
PI3K/AKT	modulates	pathway	0.85
TRIM21	promotes	protein	0.85
SQSTM1	modulates	protein	0.85
HO-1	prevents	protein	0.85
P62	regulates	protein	0.85
SIRT1	inhibits	gene	0.85
PRKAA1	modulates	gene	0.85
brain lipid metabolism	modulates	pathway	0.85
melatonin	inhibits	drug	0.85
HO-1	suppresses	protein	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

oxidative stress

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)