concept

LPCAT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LPCAT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

3Hypotheses

0Analyses

41Outgoing

24Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LPCAT3
Key Genes/Proteins	ACSL4, NOX
Related Diseases	LIPID_PEROXIDATION, Als, Ms, Ischemia, Stroke
Linked Hypotheses	3 hypotheses

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LPCAT3["LPCAT3"]
    LPCAT3 -->|"activates"| LIPID_PEROXIDATION["LIPID_PEROXIDATION"]
    LPCAT3 -->|"activates"| Als["Als"]
    LPCAT3 -->|"activates"| Ms["Ms"]
    LPCAT3 -->|"inhibits"| Ischemia["Ischemia"]
    LPCAT3 -->|"inhibits"| Stroke["Stroke"]
    LPCAT3 -->|"activates"| Fibrosis["Fibrosis"]
    LPCAT3 -->|"activates"| Tumor["Tumor"]
    LPCAT3 -->|"activates"| ALS["ALS"]
    LPCAT3 -->|"regulates"| ACSL4["ACSL4"]
    ACSL4 -->|"regulates"| LPCAT3
    SPHK1["SPHK1"] -->|"interacts"| LPCAT3
    LOX["LOX"] -->|"inhibits"| LPCAT3
    FERROPTOSIS["FERROPTOSIS"] -->|"inhibits"| LPCAT3
    TFR1["TFR1"] -->|"inhibits"| LPCAT3
    GPX4["GPX4"] -->|"inhibits"| LPCAT3
    HK2["HK2"] -->|"activates"| LPCAT3
    ALOX5["ALOX5"] -->|"activates"| LPCAT3

Outgoing (41)

Target	Relation	Type	Str
LIPID_PEROXIDATION	activates	phenotype	0.72
Als	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Ischemia	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Fibrosis	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Diabetes	activates	disease	0.65
ACSL4	regulates	gene	0.60
NOX	activates	gene	0.60
POR	regulates	gene	0.60
Ferroptosis	regulates	pathway	0.60
NOX	regulates	gene	0.60
SOAT1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
GPX4	interacts_with	gene	0.60
POR	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
Ferroptosis	inhibits	pathway	0.60
Ferroptosis	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
ROS	activates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
AND	activates	gene	0.60
AMYLOID	activates	gene	0.60
APP	activates	gene	0.60
GSR	activates	gene	0.60
GPX4	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
VDAC2	activates	gene	0.60
DMT1	activates	gene	0.60
CYBB	activates	gene	0.60
ATF4	activates	gene	0.60
Ras	activates	protein	0.60
ferroptosis	participates_in	pathway	0.60
ferroptosis	regulates	process	0.60
unfolded protein response	participates_in	pathway	0.55

Incoming (24)

Source	Relation	Type	Str
h-var-e4cae9d286	targets_gene	hypothesis	0.90
h-var-c56b26facf	targets_gene	hypothesis	0.90
h-var-70a95f9d57	targets_gene	hypothesis	0.90
ACSL4	regulates	gene	0.60
SPHK1	interacts_with	gene	0.60
LOX	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
TFR1	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
HK2	activates	gene	0.60
ALOX5	activates	gene	0.60
ACSL4	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
ROS	activates	gene	0.60
POR	regulates	gene	0.60
NOX	activates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
GPX4	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
POR	interacts_with	gene	0.60
NRF2	activates	gene	0.60
HMOX1	activates	gene	0.60
ferroptosis	regulates	phenotype	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.485	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
LPCAT3 deficiency Drives phospholipid remodeling and mitochondrial oxidative dys [PMID:41951050]	Shao G, Ye C, Sun C, Pan J, Lu L et al.	J Adv Res	2026	0

LPCAT3

Understanding Entity Pages

Wiki Pages (6)

Ferroptosis in Neurodegeneration

Ferroptosis

Ferroptosis and Lipid Peroxidation in 4R-Tauopathies

Lipid Peroxidation in Neurodegeneration