gene

ACVR1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACVR1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

Activin A Receptor Type 1B (ACVR1B)

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🧬 Gene Info

Gene Symbol	ACVR1B
Protein Type	Serine/Threonine Kinase
Function	is a type I serine/threonine kinase receptor that plays a critical role in TGF-β/activin signaling pathways.
Primary Expression	the central nervous system and has been increasingly recognized for its involvement in neurodegenerative disease pathogenesis
GeneCards	ACVR1B
Human Protein Atlas	ACVR1B
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Activin A Receptor Type 1B (ACVR1B)

gene · 1933 words

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Pathway Diagram

graph TD
    ACVR1B["ACVR1B
Activin Receptor 1B"]
    ACTIVIN["Activin A/B
Ligands"]
    SMAD2["SMAD2/3
Transcription Factors"]
    SMAD4["SMAD4
Co-SMAD"]
    TGF_PATHWAY["TGF-beta Signaling
Pathway"]
    NEUROINFLAM["Neuroinflammation"]
    MICROGLIA["Microglial
Activation"]
    ASTROCYTE["Astrocyte
Reactivity"]
    SYNAPTIC["Synaptic
Dysfunction"]
    NEURONAL_DEATH["Neuronal
Cell Death"]
    PROTEIN_AGG["Protein
Aggregation"]
    NEURODEGEN["Neurodegeneration"]
    NEUROPROT["Neuroprotective
Responses"]
    BBB["Blood-Brain Barrier
Disruption"]

    ACTIVIN -->|"binds"| ACVR1B
    ACVR1B -->|"phosphorylates"| SMAD2
    SMAD2 -->|"complexes with"| SMAD4
    SMAD4 -->|"activates"| TGF_PATHWAY
    TGF_PATHWAY -->|"promotes"| NEUROINFLAM
    TGF_PATHWAY -->|"activates"| NEUROPROT
    NEUROINFLAM -->|"activates"| MICROGLIA
    NEUROINFLAM -->|"activates"| ASTROCYTE
    MICROGLIA -->|"promotes"| SYNAPTIC
    ASTROCYTE -->|"contributes to"| BBB
    SYNAPTIC -->|"leads to"| NEURONAL_DEATH
    BBB -->|"accelerates"| PROTEIN_AGG
    PROTEIN_AGG -->|"causes"| NEURODEGEN
    NEURONAL_DEATH -->|"results in"| NEURODEGEN

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#ffffff

    class ACVR1B central
    class NEUROPROT protective
    class NEUROINFLAM,MICROGLIA,ASTROCYTE,SYNAPTIC,NEURONAL_DEATH,PROTEIN_AGG,NEURODEGEN,BBB pathological
    class ACTIVIN,SMAD2,SMAD4,TGF_PATHWAY regulatory

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
genes-acvr1b	describes	wiki	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACVR1B in their description or question text

No additional research found