Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about gut barrier: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| IL-22 | decreases_risk | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| H7: Enteric Nervous System Alpha-Synuclein Propagation Block | 0.620 | neurodegeneration | How does engineered C. butyricum cross t |
| Gut Barrier Permeability-α-Synuclein Axis Modulation | 0.533 | neurodegeneration | What are the mechanisms by which gut mic |
| Gut Barrier Restoration to Prevent Bacterial Translocation a | 0.000 | - | Gut-Brain Axis Therapeutics for Alzheime |
| Gut Barrier Reconstruction via Polysaccharide-Probiotic Synb | 0.000 | - | Gut-Brain Axis Therapeutics for AD |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.699
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for P | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiation Mechanis | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Computational Modeling of Alpha-Synuclein Propagation in PD | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Alpha-Synuclein Seed Amplification Assay Validation | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Antiviral Therapy Trial for Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Alpha-Synuclein Staging and Spreading in DLB — Spatial Propagation Map | validation | Parkinson's Disease | 0.400 | 0.50 | cell_line | proposed | $160,000 |
| Genetic Risk Modifiers in DLB Phenotype | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Tau Co-Pathology in DLB Clinical Heterogeneity | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Gut-Brain Axis Pathogenesis in Parkinson's Disease — Mechanism and Int | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Betulinic Acid Reduces Intestinal Inflammation and Enhances Intestinal Tight Jun [PMID:40647158] | ["Zheng X", "Cao Z", "Wang M", "Yuan R", | Nutrients | 2025 | 1 |
| Claudins proteins in brain tumors: expression patterns and therapeutic target. [PMID:41399659] | ["Romanowicz A", "\u0141ukaszewicz-Zaj\u | Biochemia medica | 2026 | 0 |
| Lonicerae flos and turmeric extracts alleviate necrotic enteritis in broilers by [PMID:40781642] | ["Liu X", "Ji Y", "Lv H", "Wang Z", "Lv | Journal of animal science and | 2025 | 0 |
| Lianweng formula restores intestinal barrier function in ulcerative colitis thro [PMID:40815948] | ["Lv J", "Fu Y", "Huang S", "Han C", "Zh | Phytomedicine : international | 2025 | 0 |
| Microbiota-gut-brain axis in neurodegenerative diseases: molecular mechanisms an [PMID:40952592] | ["Chen C", "Wang G", "Li D", "Zhang F"] | Molecular biomedicine | 2025 | 0 |
| Engineered Probiotics Enable Targeted Gut Delivery of Dual Gasotransmitters for [PMID:40091878] | ["Ma T", "Gan G", "Cheng J", "Shen Z", " | Angewandte Chemie (Internation | 2025 | 0 |
| Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional p [PMID:40018968] | Gowrikumar S, Tarudji A, McDonald BZ, Ba | Tissue barriers | 2025 | 0 |
| Fermented Soy Protein Maillard Product Prevents Bone Loss via TNF-α Suppression [PMID:41466098] | ["Bae H", "Joung J", "Choi H", "Han J", | Journal of microbiology and bi | 2025 | 0 |
| Transcriptional dysregulation of skin barrier genes in atopic dermatitis and pso [PMID:40885142] | ["Che-Wen Y", "Lin F", "Chen K", "Cheng | Biomedicine & pharmacotherapy | 2025 | 0 |
| Zn glycine mitigates the LPS-induced hepatic injury and inflammation through NrF [PMID:40957293] | ["Zulfiqar Z", "Asif M", "Al-Mitib L", " | Poultry science | 2025 | 0 |
| Traditional Chinese herbal medicines for the treatment of ischemic stroke in Chi [PMID:40516828] | ["Dong X", "Zhang T", "Zhang C", "Shang | Ageing research reviews | 2025 | 0 |
| Polystyrene microplastic-induced oxidative stress triggers intestinal barrier dy [PMID:38301820] | Zeng G, Li J, Wang Y, Su J, Lu Z, Zhang | Environmental pollution (Barki | 2024 | 0 |
| Acrolein suppresses anticancer drug-induced toxicity mediated by activating clau [PMID:38142011] | ["Eguchi H", "Yu Y", "Matsunaga T", "Yos | Toxicology letters | 2024 | 0 |
| Exposure to Progestin 17-OHPC Induces Gastrointestinal Dysfunction through Claud [PMID:38583420] | ["Zeng L", "Zhang X", "Shen Q", "He L", | Neuroendocrinology | 2024 | 0 |
| Untitled [PMID:37492530] | ["Lei W", "Cheng Y", "Gao J", "Liu X", " | Frontiers in cellular and infe | 2023 | 0 |
| Effects of prebiotics on intestinal physiology, neuropsychological function, and [PMID:36869551] | ["Chung Y", "Wu J", "Huang W"] | Food research international (O | 2023 | 0 |
| The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders. [PMID:36611848] | ["Anand N", "Gorantla V", "Chidambaram S | Cells | 2022 | 0 |
| Mammary tumors alter the fecal bacteriome and permit enteric bacterial transloca [PMID:35248004] | ["Loman B", "Russart K", "Grant C", "Lyn | BMC cancer | 2022 | 0 |
| Co-exposure to boscalid and TiO [PMID:35559963] | ["Cao X", "Khare S", "DeLoid G", "Gokula | NanoImpact | 2021 | 0 |
| Co-exposure to boscalid and TiO [PMID:33869896] | ["Cao X", "Khare S", "DeLoid G", "Gokula | NanoImpact | 2021 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning gut barrier in their description or question text
No additional research found