concept

IL-22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

0Analyses

44Outgoing

29Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	IL-22
Key Genes/Proteins	ALZHEIMER, IL-1, IL-4
Related Diseases	Alzheimer, Als, Neuroinflammation, Tumor, ALS
Related Pathways	Th17/Th22 Pathway

Wiki Pages (17)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IL_22["IL-22"]
    IL_22 -->|"involved_in"| Th17_Th22_Pathway["Th17/Th22 Pathway"]
    IL_22 -->|"activates"| Alzheimer["Alzheimer"]
    IL_22 -->|"activates"| Als["Als"]
    IL_22 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    IL_22 -->|"activates"| Tumor["Tumor"]
    IL_22 -->|"activates"| ALS["ALS"]
    IL_22 -->|"activates"| Inflammation["Inflammation"]
    NRF2["NRF2"] -->|"activates"| IL_22
    IL_10["IL-10"] -->|"activates"| IL_22
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| IL_22
    TNF["TNF"] -->|"activates"| IL_22
    CYTOKINES["CYTOKINES"] -->|"activates"| IL_22
    ALZHEIMER["ALZHEIMER"] -->|"activates"| IL_22
    APP["APP"] -->|"activates"| IL_22
    IL_4["IL-4"] -->|"activates"| IL_22

Outgoing (44)

Target	Relation	Type	Str
Th17/Th22 Pathway	involved_in	pathway	0.80
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Anxiety	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Stroke	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
ALZHEIMER	activates	gene	0.60
IL-1	activates	gene	0.60
IL-4	activates	gene	0.60
IL-17	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
APP/PS1	activates	gene	0.60
IL-6	activates	gene	0.60
IL-10	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-17	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
SYP	inhibits	gene	0.60
TAU	activates	gene	0.60
ANXIETY	activates	gene	0.60
IL-6	inhibits	gene	0.60
Oxidative Stress	activates	pathway	0.60
Neuron	activates	cell_type	0.60
Amyloid	activates	pathway	0.60
Tau Phosphorylation	activates	pathway	0.60
Aβ	activates	protein	0.60
Interleukin	activates	protein	0.60
Cytokine	activates	protein	0.60
Amyloid-Beta	activates	protein	0.60
Bdnf	inhibits	protein	0.60
STROKE	therapeutic_target	gene	0.60
RORC	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
AHR	inhibits	gene	0.60
Cytokine	inhibits	protein	0.60
App	activates	protein	0.60
Il-1	inhibits	protein	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (29)

Source	Relation	Type	Str
NRF2	activates	gene	0.60
IL-10	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
TNF	activates	gene	0.60
CYTOKINES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APP	activates	gene	0.60
IL-4	activates	gene	0.60
IL-6	activates	gene	0.60
IL-17	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
GUT-BRAIN AXIS	activates	gene	0.60
AND	activates	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
TNF-Α	activates	gene	0.60
ANXIETY	activates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
TAU	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
IL-6	inhibits	gene	0.60
IL-17	inhibits	gene	0.60
AND	inhibits	gene	0.60
SYP	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
IL-1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL-22

Understanding Entity Pages

Wiki Pages (17)

Multiple Sclerosis (MS)

IL28B (Interleukin 28B)

Adaptive Immunity in Neurodegeneration

IL-10 Protein

IL20 (Interleukin 20)

RORC Gene

IL28A (Interleukin-28A)

RORγ Protein

IL23A Gene

Multiple Sclerosis Mechanistic Pathway

TYK2 Protein — Tyrosine Kinase 2

IL24 — Interleukin 24

IL26 Gene

Tertiary Lymphoid Organs in Neurodegeneration

IL22