concept

LYSOSOMAL PH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYSOSOMAL PH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

3Hypotheses

3Analyses

2Outgoing

17Incoming

0Experiments

3Debates

No summary available yet.

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💡 Concept Info

Name	LYSOSOMAL PH

Pathway Diagram

graph TD
    LYSOSOMAL_PH[LYSOSOMAL PH]
    LYSOSOMAL_PH -->|regulates| TFEB[TFEB]
    Lyso_ArchT[Lyso-ArchT] -->|regulates| LYSOSOMAL_PH
    Lyso_Chr2[Lyso-Chr2] -->|regulates| LYSOSOMAL_PH
    Lamp_Tmem175_Interaction[Lamp-Tmem175 Interaction] -->|regulates| LYSOSOMAL_PH
    tetrandrine[tetrandrine] -->|upregulates| LYSOSOMAL_PH
    SLC45A1[SLC45A1] -->|regulates| LYSOSOMAL_PH
    V_Atpase_V1_Subunits[V-Atpase V1 Subunits] -->|regulates| LYSOSOMAL_PH
    Lyso_Archt[Lyso-Archt] -->|modulates| LYSOSOMAL_PH
    Lyso_Nphr3_0[Lyso-Nphr3.0] -->|regulates| LYSOSOMAL_PH

Outgoing (2)

Target	Relation	Type	Str
lysosomal function	modulates	process	0.70
Cathepsin D activation	modulates	mechanism	0.70

Incoming (17)

Source	Relation	Type	Str
SLC45A1	regulates	protein	0.90
Lyso-ArchT	regulates	protein	0.90
V-Atpase V1 Subunits	regulates	protein	0.90
Lamp-Tmem175 Interaction	regulates	mechanism	0.90
Lyso-Chr2	regulates	protein	0.90
tetrandrine	upregulates	compound	0.90
Lyso-Archt	modulates	protein	0.88
Lyso-Nphr3.0	regulates	protein	0.85
Lyso-Nphr3.0	modulates	protein	0.85
Lyso-ArchT	modulates	protein	0.85
V-ATPase	regulates	protein	0.85
Lyso-NpHR3.0	regulates	protein	0.82
SLC45A1 loss	upregulates	phenotype	0.80
V-Atpase	regulates	protein	0.70
lyso-ArchT	modulates	protein	0.70
v-ATPase	modulates	protein	0.70
ATP6V1A	regulates	gene	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal pH Restoration Upstream of TFEB	0.619	neurodegeneration	Does TFEB dysfunction cause neurodegener
Lysosomal pH Gradient Manipulation	0.455	neurodegeneration	How do host cell factors influence the c
Lysosomal pH Microdomains Restoration	0.000	-	Autophagy-lysosome pathway convergence a

Mentioning Analyses (3)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 19 hypotheses Top: 0.591

How do host cell factors influence the conformation and propagation properties o

neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.455

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.777

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Protective Role of Purslane Supplementation Against Cadmium-Induced Renal and Gi [PMID:40877613]	Alsubaie N, Abd-Elhakim YM, Mohamed AA,	Biol Trace Elem Res	2026
Ginsenoside Rg5 inhibits colorectal cancer, at least partially by blocking the l [PMID:41639226]	Guo X, Sun R, Su Y, Qin Q, Liu Y et al.	Sci Rep	2026
Real-time visualization of drug-target interactions in native subcellular microe [PMID:41756019]	Wang R, Yuan Y, Shao H, Sun Y, Lai C et	J Pharm Anal	2026

Debates (3)

Multi-agent debates referencing this entity

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

How do host cell factors influence the conformation and propagation properties o

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning LYSOSOMAL PH in their description or question text

No additional research found