ID: hyp-SDA-2026-04-08-gap-pubmed-20260406-0
Hypothesis

Lysosomal pH Gradient Manipulation

Therapeutic fine-tuning of lysosomal pH through v-ATPase modulation to optimize seed degradation while preventing toxic fragment formation.
🧬 ATP6V1A🩺 neurodegeneration🎯 Composite 46%💱 $0.52▲6.0%active
EvidencePending (0%)📖 5 cit🗣 1 debates 5 support 1 oppose
✓ All Quality Gates Passed
Mechanistic 0.50 (15%) Evidence 0.50 (15%) Novelty 0.50 (12%) Feasibility 0.50 (12%) Impact 0.00 (12%) Druggability 0.50 (10%) Safety 0.50 (8%) Competition 0.50 (6%) Data Avail. 0.50 (5%) Reproducible 0.50 (5%) KG Connect 0.50 (8%) 0.455 composite

🧪 Overview

Therapeutic fine-tuning of lysosomal pH through v-ATPase modulation to optimize seed degradation while preventing toxic fragment formation

🧬 Mechanism

🔗 Mechanism from KG for ATP6V1A

Auto-built from this analysis's top knowledge-graph edges.

graph TD
    ATP6V1A["ATP6V1A"] -->|encodes subunit of| v_ATPase["v-ATPase"]
    ATP6V1A_1["ATP6V1A"] -->|encodes subunit of| lysosomal_acidification["lysosomal acidification"]
    ATP6V1A_2["ATP6V1A"] -->|associated with| neurodegeneration["neurodegeneration"]
    style ATP6V1A fill:#ce93d8,stroke:#333,color:#000
    style v_ATPase fill:#4fc3f7,stroke:#333,color:#000
    style ATP6V1A_1 fill:#ce93d8,stroke:#333,color:#000
    style lysosomal_acidification fill:#81c784,stroke:#333,color:#000
    style ATP6V1A_2 fill:#ce93d8,stroke:#333,color:#000
    style neurodegeneration fill:#ef5350,stroke:#333,color:#000

⚖️ Evidence

⚖️ Evidence Matrix5 supports0 contradicts
Supports
ATM loss disrupts the autophagy-lysosomal pathway.
Autophagy2021PMID:32757690medium
Supports
Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.
Autophagy2019PMID:30917721medium
Supports
Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification.
Cell Death Dis2024PMID:39138191medium
Supports
Metabolic Cardiomyopathies and Cardiac Defects in Inherited Disorders of Carbohydrate Metabolism: A Systematic Review.
Int J Mol Sci2023PMID:37239976medium
Supports
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Redox Biol2022PMID:35325805medium
📖 Linked Papers

No linked papers recorded for this hypothesis yet.

🏥 Translation

🧬 3D Protein Structure — ATP6V1A

No curated PDB or AlphaFold mapping for ATP6V1A yet. Search RCSB →

💉 Clinical Trials

No clinical trials data linked to this hypothesis yet.

No curated ClinVar variants loaded for this hypothesis.

Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.

🔍 Search ClinVar for ATP6V1A →

No DepMap CRISPR Chronos data found for ATP6V1A.

Run python3 scripts/backfill_hypothesis_depmap.py to populate.

🏆 Tournament

🏆 Arenas / Elo

No arena matches recorded yet. Browse Arenas →

📊 Market Indicators

7d Trend
Stable
7d Momentum
▲ 0.0%
Volatility
High
0.0535
Events (7d)
0
Price History
▲6.0%

💾 Resource Usage

LLM Tokens
15,500
$0.0930
Total Cost
$0.0930
Metadatasource: v1_phase_c_backfill · origin_type: debate_synthesis
sourcev1_phase_c_backfill
origin_typedebate_synthesis
_schema_version1
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting 0 contradicting 0 neutral
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