entity

ATP6V1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP6V1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

3Hypotheses

3Analyses

14Outgoing

4Incoming

0Experiments

3Debates

No AI portrait yet

Outgoing (14)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATP6V1A	data_in	dataset_row	0.00
h-652a706ec8	targeted_by	hypothesis	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
v-ATPase	encodes_subunit_of	protein	0.90
lysosomal acidification	encodes_subunit_of	pathway	0.90
lysosomal acidification	regulates	pathway	0.70
neurodegeneration	associated_with	disease	0.70
lysosomal pH	regulates	process	0.50
lysosomal_acidification	enables	process	0.50
YWHAG	co_associated_with	gene	0.40
ULK1	co_associated_with	gene	0.40
LAMTOR1	co_associated_with	gene	0.40
TFEB	co_associated_with	gene	0.40
TFE3	co_associated_with	gene	0.40

Incoming (4)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATP6V1A	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
h-652a706ec8	targets	hypothesis	1.00
h-6b394be1	targets	hypothesis	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal pH Restoration Upstream of TFEB	0.619	neurodegeneration	Does TFEB dysfunction cause neurodegener
Lysosomal pH Gradient Manipulation	0.455	neurodegeneration	How do host cell factors influence the c
Lysosomal pH Microdomains Restoration	0.000	-	Autophagy-lysosome pathway convergence a

Mentioning Analyses (3)

Scientific analyses that reference this entity

How do host cell factors influence the conformation and propagation properties o

neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.455

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.697

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.777

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Protective Role of Purslane Supplementation Against Cadmium-Induced Renal and Gi [PMID:40877613]	Alsubaie N, Abd-Elhakim YM, Mohamed AA,	Biol Trace Elem Res	2026
Ginsenoside Rg5 inhibits colorectal cancer, at least partially by blocking the l [PMID:41639226]	Guo X, Sun R, Su Y, Qin Q, Liu Y et al.	Sci Rep	2026
Real-time visualization of drug-target interactions in native subcellular microe [PMID:41756019]	Wang R, Yuan Y, Shao H, Sun Y, Lai C et	J Pharm Anal	2026

Debates (3)

Multi-agent debates referencing this entity

How do host cell factors influence the conformation and propagation properties o

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

The debate highlighted TFEB's role in mitochondrial-lysosomal coupling but could

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning ATP6V1A in their description or question text

No additional research found