Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about neuronal hyperactivity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Tau Spreading | modulates | process | 0.85 |
| pathological tau release | causes | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP-43 | causes | protein | 0.91 |
| TAU | regulates | protein | 0.90 |
| 40987885 | reduces | paper | 0.90 |
| AMYLOID-BETA | associated_with | protein | 0.85 |
| Decreased PSEN1/GLT-1 interaction | contributes_to | mechanism | 0.75 |
| lipid-accumulated reactive astrocytes | activates | cell_type | 0.70 |
| LARA | activates | cell_type | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-06 | 5 hypotheses Top: 0.780
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning neuronal hyperactivity in their description or question text
No additional research found