Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about opsin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neurons | activates | cell_type | 0.95 |
| astrocytes | modulates | cell_type | 0.85 |
| microglia | modulates | cell_type | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| adeno-associated viruses | targets | drug | 0.92 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Optogenetic Microglial Deactivation via Engineered Inhibitor | 0.384 | neurodegeneration | Synaptic pruning by microglia in early A |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer's [PMID:39908361] | Wu X, Miller JA, Lee BTK, Wang Y, Ruedl | Sci Adv | 2025 | 1 |
| Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via [PMID:37465997] | Chen X, He X, Xu F, Xu N, Sharifi NH, Zh | Stroke | 2023 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. [PMID:34492237] | Subbarayan MS, Joly-Amado A, Bickford PC | Pharmacol Ther | 2022 | 1 |
| Microglia in neurodegeneration. [PMID:30258234] | Hickman S, Izzy S, Sen P, Morsett L, El | Nat Neurosci | 2018 | 1 |
| Spatiotemporal dynamic regulation of the CX3CL1-CX3CR1 axis: A double-edged swor [PMID:41564496] | Liang J, Zhu W, Pan R, Wei S, Zhang S et | Cytokine Growth Factor Rev | 2026 | 0 |
| CD8(+) T(EMRA) cells: A double-edged sword in immunity and disease-Mechanisms an [PMID:41946125] | Ma J, Wu Y, Chen L, Zheng X | Int Immunopharmacol | 2026 | 0 |
| Aging effects on emotionality, cognition and brain mononuclear cells in Sprague- [PMID:41946716] | Djuretić J, Ivanović J, Jezdić K, Todoro | NPJ Aging | 2026 | 0 |
| Cx3Cr1-Cre induction leads to microglial activation and IFN-1 signaling caused b [PMID:35045285] | Sahasrabuddhe V, Ghosh HS | Cell reports | 2022 | 0 |
| Cellular connectomes as arbiters of local circuit models in the cerebral cortex. [PMID:33986261] | ["Klinger E", "Motta A", "Marr C", "Thei | Nature communications | 2021 | 0 |
| High-performance brain-to-text communication via handwriting. [PMID:33981047] | ["Willett F", "Avansino D", "Hochberg L" | Nature | 2021 | 0 |
| Lower excitatory synaptic gene expression in orbitofrontal cortex and striatum i [PMID:31168067] | ["Piantadosi S", "Chamberlain B", "Glaus | Molecular psychiatry | 2021 | 0 |
| Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular [PMID:31474370] | ["Martin J", "Chang C", "Boschetti G", " | Cell | 2019 | 0 |
| De novo NSF mutations cause early infantile epileptic encephalopathy. [PMID:31675180] | ["Suzuki H", "Yoshida T", "Morisada N", | Annals of clinical and transla | 2019 | 0 |
| Trabeculectomy training in England: are we safe at training? Two year surgical o [PMID:29527013] | ["Walkden A", "Huxtable J", "Senior M", | Eye (London, England) | 2018 | 0 |
| Subcycle observation of lightwave-driven Dirac currents in a topological surface [PMID:30258232] | ["Reimann J", "Schlauderer S", "Schmid C | Nature | 2018 | 0 |
| Directed Differentiation of Human Pluripotent Stem Cells to Microglia. [PMID:28528700] | Douvaras P, Sun B, Wang M, Kruglikov I, | Stem cell reports | 2017 | 0 |
| Distinct forms of synaptic inhibition and neuromodulation regulate calretinin-po [PMID:27045594] | ["Smith K", "Boyle K", "Mustapa M", "Job | Neuroscience | 2016 | 0 |
| Architecture of the mammalian mechanosensitive Piezo1 channel. [PMID:26390154] | ["Ge J", "Li W", "Zhao Q", "Li N", "Chen | Nature | 2015 | 0 |