cell_type

astrocytes

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about astrocytes: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5678Connections

2Hypotheses

22Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	astrocytes
Definition	<table class="infobox infobox-celltype">
Key Markers	CHI3L1, BMAL1, IL-6, Connexin43, YKL-40, AMYLOID-BETA, CONNEXIN43, ALKBH5
Key Pathways	insulin signaling, oxidative stress response, unfolded protein response, neurotrophin signaling, complement cascade
Associated Diseases	NREM Sleep, Parkinson's Disease, Postoperative Cognitive Dysfunction, Alzheimer Disease, Parkinson Disease, Huntington Disease
Linked Hypotheses	156 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Pathway Diagram

graph TD
    astrocytes["astrocytes"] -->|"expresses"| IL_6["IL-6"]
    style IL_6 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    astrocytes["astrocytes"] -->|"produces"| GFAP["GFAP"]
    style GFAP fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    astrocytes["astrocytes"] -->|"interacts"| GnRH_neurons["GnRH neurons"]
    style GnRH_neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    astrocytes["astrocytes"] -->|"activates"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    astrocytes["astrocytes"] -->|"expressed in"| mPFC["mPFC"]
    style mPFC fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    astrocytes["astrocytes"] -->|"protects against"| motor_neurons["motor neurons"]
    style motor_neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    astrocytes["astrocytes"] -->|"activates"| multiple_sclerosis["multiple sclerosis"]
    style multiple_sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ALKBH5["ALKBH5"] -->|"expressed in"| astrocytes["astrocytes"]
    style ALKBH5 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    kisspeptin["kisspeptin"] -->|"activates"| astrocytes["astrocytes"]
    style kisspeptin fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"associated"| astrocytes["astrocytes"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    neuroinflammation["neuroinflammation"] -->|"affects"| astrocytes["astrocytes"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AQP4["AQP4"] -->|"activates"| astrocytes["astrocytes"]
    style AQP4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style astrocytes fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (3134)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
IL-6	expresses	protein	0.95
GFAP	produces	protein	0.90
GnRH neurons	interacts_with	cell_type	0.90
neurodegeneration	activates	disease	0.90
neurovascular unit inflammation	involved_in	process	0.90
blood-brain barrier	involved_in	process	0.90
LRP1	expressed_in	gene	0.90
HK2-PINK1-mediated mitophagy	expressed_in	pathway	0.90
A1 phenotype	associated_with	phenotype	0.88
mPFC	expressed_in	brain_region	0.85
insulin signaling	active_in	pathway	0.85
oxidative stress response	active_in	pathway	0.85
unfolded protein response	active_in	pathway	0.85
neurotrophin signaling	active_in	pathway	0.85
complement cascade	active_in	pathway	0.85
senescence	active_in	pathway	0.85
mitochondrial function	active_in	pathway	0.85
cytokine-induced neuronal death	protects_against	phenotype	0.85
neuronal damage	contributes_to	phenotype	0.85
neuronal metabolism	regulates	process	0.85
motor neurons	protects_against	cell_type	0.80
multiple sclerosis	activates	disease	0.80
Alzheimer's disease	activates	disease	0.80
neurodegeneration	contributes_to	phenotype	0.80
purinergic signaling	active_in	pathway	0.75
glutamate signaling	active_in	pathway	0.75
NAD+ metabolism	active_in	pathway	0.75
circadian regulation	active_in	pathway	0.75
glymphatic clearance	active_in	pathway	0.75
synaptic plasticity	active_in	pathway	0.75
JAK-STAT signaling	active_in	pathway	0.75
lipid metabolism	active_in	pathway	0.75
synapses	targets	process	0.75
lipid metabolism dysregulation	involved_in	process	0.75
neuroinflammation	associated_with	process	0.70
α-synuclein	regulates	protein	0.70
neuroinflammation	regulates	process	0.70
NRF2	regulates	protein	0.70
CNS function	regulates	process	0.70
MMP9	expressed_in	protein	0.70
neuroinflammation	activates	process	0.70
proinflammatory cytokines	activates	protein	0.70
mutant Huntingtin clearance	activates	process	0.70
immunosuppressive tumour microenvironment	regulates	process	0.70
glioblastoma	associated_with	disease	0.70
immune response	regulates	process	0.70
Parkinson	contributes_to	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
amyloid aggregation	associated_with	process	0.70

Incoming (2544)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
ALKBH5	expressed_in	protein	0.95
kisspeptin	activates	protein	0.92
RNA	associated_with	gene	0.90
neuroinflammation	affects	disease	0.90
AQP4	activates	gene	0.90
neurodegeneration	affects	disease	0.90
multiple sclerosis	affects	disease	0.90
unfolded protein response	active_in	pathway	0.90
lipid metabolism	active_in	pathway	0.90
NLRP3	activates	gene	0.90
AQP4	associated_with	gene	0.90
Alzheimer's disease	affects	disease	0.90
Parkinson's disease	affects	disease	0.90
C3	activates	gene	0.90
C3	inhibits	gene	0.90
AQP4	inhibits	gene	0.90
ALS	affects	disease	0.90
C3	expressed_in	gene	0.90
NF-kB signaling	active_in	pathway	0.90
TNF	activates	gene	0.90
aging	affects	disease	0.90
GFAP	activates	gene	0.90
GFAP	associated_with	gene	0.90
GFAP	expressed_in	gene	0.90
epilepsy	affects	disease	0.90
synaptic plasticity	active_in	pathway	0.90
Huntington's disease	affects	disease	0.90
depression	affects	disease	0.90
anxiety	affects	disease	0.90
pyroptosis	active_in	pathway	0.90
stroke	affects	disease	0.90
RNA	activates	gene	0.90
APP	associated_with	gene	0.90
PS1	expressed_in	gene	0.90
axon	found_in	organelle	0.90
HK2-PINK1 pathway	expressed_in	pathway	0.90
mitophagy	expressed_in	process	0.90
Mct8 Deficiency	causes_alterations_in	condition	0.90
PINK1	expressed_in	gene	0.85
IL-6	expressed_in	gene	0.85
GDNF	expressed_in	gene	0.85
TREM2	expressed_in	gene	0.85
opsin	modulates	protein	0.85
autophagy dysregulation	contributes_to	phenotype	0.85
amyloid beta	activates	protein	0.80
APOE	regulates	gene	0.80
complement cascade	active_in	pathway	0.80
APOE	activates	gene	0.80
AQP4	implicated_in	gene	0.80

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
AMPK hypersensitivity in astrocytes creates enhanced mitocho	0.570	neurodegeneration	Mitochondrial transfer between astrocyte
Circadian Rhythm Entrainment of Reactive Astrocytes	0.481	neurodegeneration	Astrocyte reactivity subtypes in neurode

Mentioning Analyses (22)

Scientific analyses that reference this entity

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.596

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.610

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

molecular biology | 2026-04-13 | 0 hypotheses

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

cellular senescence | 2026-04-11 | 0 hypotheses

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

neurodegeneration | 2026-04-06 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168]	Ruan W, Li T, Bang IH, Lee J, Deng W, Ma	Nature	2025	1
Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923]	Fernandes M, Liguori C	Handb Clin Neurol	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504]	Hussain Y, Dar MI, Pan X	Metabolites	2024	1
Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017]	Zeng Y, Guo Z, Wu M, Chen F, Chen L	Cell Death Discov	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594]	Pan X, Mota S, Zhang B	Adv Exp Med Biol	2020	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuro [PMID:26121488]	Hang L, Thundyil J, Lim KL	Ann N Y Acad Sci	2015	1
AMPKα1 Deficiency in Macrophages Impairs Tendon Regeneration and Tendon Stem Cel [PMID:41694579]	Zhu L, Wang Y, Shi X, Yu M, Cai X, Chen	International journal of biolo	2026	0
Single-cell transcriptome analysis reveals a cellular immune response in common [PMID:41692207]	Shi X, Ji G, Liu D, Zhao T, Tian S, Li S	International journal of biolo	2026	0
Farrerol ameliorates hepatic insulin resistance via AMPKα1/mTOR/SREBP-1 pathway: [PMID:41702183]	Li Y, Feng X, Zheng L	Tissue & cell	2026	0
Integration proteomics analysis to identify AMPK as key target pathways of TCM f [PMID:41788172]	Chen YJ, Ning DS, Wang CC, Zhao HW, Wang	Journal of traditional and com	2026	0
Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoart [PMID:41791307]	Zhai Y, Zhou P, Dan L, Ma M, Liu B, Zhan	International immunopharmacolo	2026	0
Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011]	Wu L, Dong YT, Mu X, Luo X, Chen ZJ	The journal of prevention of A	2026	0
BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150]	Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa	Biochemistry and biophysics re	2026	0
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646]	Lin L, Liang X, Xu Z, Li Y, Guo Z et al.	Biomaterials	2026	0
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525]	Sica V, Sato T, Tsialtas I, Hernandez S,	J Biol Rhythms	2026	0
Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008]	Tsameret S, Froy O, Matz Y, Landau Z, Tw	Diabetologia	2026	0

astrocytes

Understanding Entity Pages

Wiki Pages (21)

Astrocytes in Amyotrophic Lateral Sclerosis

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Pathway Diagram

Outgoing (3134)

Incoming (2544)

Targeting Hypotheses (2)

Mentioning Analyses (22)

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

APOE4-driven lipid metabolism dysregulation in astrocytes and its role in AD

Senescent cell clearance as neurodegeneration therapy

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Which cell types show the most significant expression changes for neurodegenerat

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Extracellular vesicle biomarkers for early AD detection

Mitochondrial transfer between astrocytes and neurons

Senolytic therapy for age-related neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Mitochondrial transfer between astrocytes and neurons

Related Papers (20)

astrocytes

Understanding Entity Pages

Wiki Pages (21)

Astrocytes in Amyotrophic Lateral Sclerosis

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

Atypical Parkinsonism

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Pathway Diagram

Outgoing (3134)

Incoming (2544)

Targeting Hypotheses (2)

Mentioning Analyses (22)

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

APOE4-driven lipid metabolism dysregulation in astrocytes and its role in AD

Senescent cell clearance as neurodegeneration therapy

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Which cell types show the most significant expression changes for neurodegenerat

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Extracellular vesicle biomarkers for early AD detection

Mitochondrial transfer between astrocytes and neurons

Senolytic therapy for age-related neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Mitochondrial transfer between astrocytes and neurons

Related Papers (20)