Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about stress_response: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CRH | activates | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Multi-Modal Stress Response Harmonization | 0.601 | neurodegeneration | Digital biomarkers and AI-driven early d |
| Neuronal Integrated Stress Response Modulation | 0.452 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
| Nucleolar Stress Response Normalization | 0.378 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor p [PMID:39402629] | Wang X, Chai Y, Quan Y, Wang J, Song J, | J Hematol Oncol | 2024 | 1 |
| Significance of NPM1 Gene Mutations in AML. [PMID:34576201] | Hindley A, Catherwood MA, McMullin MF, M | Int J Mol Sci | 2021 | 1 |
| NPM1-mutated acute myeloid leukemia: from bench to bedside. [PMID:32609823] | Falini B, Brunetti L, Sportoletti P, Mar | Blood | 2020 | 1 |
| Methylation of HPA axis related genes in men with hypersexual disorder. [PMID:28319850] | Jokinen J, Boström AE, Chatzittofis A, C | Psychoneuroendocrinology | 2017 | 1 |
| Insights into the regulation of neuronal viability by nucleophosmin/B23. [PMID:25908633] | Pfister JA, D'Mello SR | Exp Biol Med (Maywood) | 2015 | 1 |
| Development of alopecia areata is associated with higher central and peripheral [PMID:19020552] | Zhang X, Yu M, Yu W, Weinberg J, Shapiro | J Invest Dermatol | 2009 | 1 |
| Functions of the histone chaperone nucleolin in diseases. [PMID:17484127] | Storck S, Shukla M, Dimitrov S, Bouvet P | Subcell Biochem | 2007 | 1 |
| Cytokine associated neuroinflammation in Parkinson's disease: Molecular pathways [PMID:41512596] | ["Dhapola R", "Kumari S", "Sharma P", "P | Cytokine & growth factor revie | 2026 | 0 |
| Long-term outcomes in FLT3-mutated acute myeloid leukemia after frontline hypome [PMID:41035402] | Short NJ, Loghavi S, Yilmaz M, Karrar O, | Haematologica | 2026 | 0 |
| A Unified Model: Chromatin-Bound Multicomponent Condensates. [PMID:41481253] | Lau BK, Haarer EL, Ahn JH, Wang GG | Cancer Res | 2026 | 0 |
| Discovery and optimization of Menin-MLL inhibitors targeting acute myeloid leuke [PMID:41666760] | Xiao Q, Wang Y, Shen Z, Mo J, Li C et al | Eur J Med Chem | 2026 | 0 |
| Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to [PMID:41923577] | Bruzzese A, Vigna E, Martino EA, Caserta | Eur J Haematol | 2026 | 0 |
| Response to Comment on: "Prognostic implications of myelodysplasia-related gene [PMID:41924903] | Chang YS, Hou HA | Haematologica | 2026 | 0 |
| Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a [PMID:41942459] | Zheng LC, Wong KKW, Lam SSY, Leung GMK, | Nat Commun | 2026 | 0 |
| CPX-351 (Liposomal Cytarabine and Daunorubicin) versus venetoclax plus hypomethy [PMID:41942467] | Fathima S, Rokach L, Ghosoun N, Rezasolt | Blood Cancer J | 2026 | 0 |
| Fibrillarin: bridging ribosome biogenesis and apoptosis in cellular stress and d [PMID:41518572] | ["Zhang Z", "Zhang M", "Cao Z", "Zhao H" | Apoptosis : an international j | 2026 | 0 |
| Neurobiological and therapeutic landmarks of depression associated with Alzheime [PMID:40529210] | ["Untu I", "Davidson M", "Stanciu G", "R | Frontiers in aging neuroscienc | 2025 | 0 |
| Neurobiological mechanisms and recent advances in drug-based therapeutics in dep [PMID:41205901] | ["Ahmadnia H", "Abdollahzadeh R", "Hatam | Neuroscience | 2025 | 0 |
| Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of [PMID:40649806] | ["Ricardi C", "Mazzierli A", "Guglielmo | International journal of molec | 2025 | 0 |
| A novel multi-target compound mitigates amyloid plaques, synaptic deficits, and [PMID:40770166] | ["Lee Y", "Han S", "Lee J", "Cho Y", "Ki | Archives of pharmacal research | 2025 | 0 |