gene

CRH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

649Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CRH is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with ALI, ALS, ALZHEIMER. Connected to 189 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CRH
Chromosome	8q13
Protein Type	Ligand
Target Class	Ligand
Function	The CRH gene encodes prepro-CRH, a precursor peptide that is processed to mature CRH.
Mechanism of Action	CRH receptor antagonist blocking stress hormone signaling
Primary Expression	brain regions involved in stress and emotion:
Druggability	Low (0.34)
Clinical Stage	Approved
Amino Acids	41 aa
Pathways	Apoptosis, Blood-Brain Barrier, Complement, HPA-axis, HPA_AXIS
UniProt ID	P06850
Ensembl ID	ENSG00000118271
GeneCards	CRH
Human Protein Atlas	CRH
Associated Diseases	ALS, Addiction, Alopecia Areata, Alzheimer, Cancer
Known Drugs/Compounds	dexamethasone
Interactions	NR3C1, TNFA, FKBP5, JUN, CRHR1, BDNF
SciDEX Target	View Target Profile (10 clinical trials)
KG Connections	649 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CRH — AlphaFold P06850 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CRH["CRH"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CRH["CRH"] -->|"interacts"| NR3C1["NR3C1"]
    CRH["CRH"] -->|"interacts"| TNFA["TNFA"]
    CRH["CRH"] -->|"co discussed"| BDNF["BDNF"]
    CRH["CRH"] -->|"co discussed"| ULK1["ULK1"]
    CRH["CRH"] -->|"co discussed"| SNCA["SNCA"]
    NR3C1_1["NR3C1"] -->|"interacts"| CRH["CRH"]
    TNFA_2["TNFA"] -->|"interacts"| CRH["CRH"]
    BMAL1["BMAL1"] -->|"co discussed"| CRH["CRH"]
    CLOCK["CLOCK"] -->|"co discussed"| CRH["CRH"]
    style CRH fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (486)

Target	Relation	Type	Str
ACTH	activates	protein	1.00
HPA-axis	regulates	pathway	0.95
Central Amygdala	expressed_in	cell_type	0.95
Hypothalamic-Pituitary-Adrenal Axis	component_of	pathway	0.90
Stress-Induced Hyperglycemia	mediates	phenotype	0.90
thalamus	expressed_in	brain_region	0.90
hypothalamus	expressed_in	brain_region	0.90
ACTH	stimulates	protein	0.90
Hpa Axis	involved_in	pathway	0.90
CRHR1	activates	protein	0.87
HPA_AXIS	participates_in	pathway	0.87
Post-Traumatic Stress Disorder	associated_with	disease	0.85
Paraventricular Nucleus	expressed_in	cell_type	0.85
Alcohol Intake	modulates	phenotype	0.85
Alopecia Areata	associated_with	disease	0.85
Alopecia Areata	upregulates	disease	0.85
CeA	expressed_in	brain_region	0.80
Hypersexual Disorder	associated_with	disease	0.80
HPA Axis Homeostasis	regulates	process	0.80
NR3C1	co_mentioned_with	gene	0.80
neurons	activates	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
neurons	releases	cell_type	0.80
stress_response	activates	pathway	0.80
HPA_AXIS	regulates	pathway	0.76
Post-Traumatic Stress Disorder	involved_in	disease	0.75
GUT_DYSBIOSIS	causes	phenotype	0.72
PVN	expressed_in	brain_region	0.72
APIR	expressed_in	brain_region	0.72
depression	implicated_in	disease	0.70
depression	associated_with	disease	0.70
amygdala	expressed_in	brain_region	0.70
neuroinflammation	activates	disease	0.70
serotonin	releases	neurotransmitter	0.70
mast cells	activates	cell_type	0.70
mast cells	regulates	cell_type	0.70
Hypersexual Disorder	biomarker_for	disease	0.70
unfolded protein response	participates_in	pathway	0.70
neurons	regulates	cell_type	0.70
cortex	expressed_in	brain_region	0.70
neurons	implicated_in	cell_type	0.70
SOCIAL_INTERACTION	inhibits	phenotype	0.68
BMA	activates	brain_region	0.68
SOCIAL_MOTIVATION	activates	phenotype	0.68
Addiction	associated_with	disease	0.65
Ptsd	inhibits	disease	0.65
Opioid	activates	disease	0.65
Addiction	activates	disease	0.65
Ptsd	associated_with	disease	0.65
Opioid	associated_with	disease	0.65

Incoming (163)

Source	Relation	Type	Str
Stress	upregulates	process	0.90
h-1e564178	targets_gene	hypothesis	0.90
PVN	produces	brain_region	0.87
DNA Methylation	regulates	mechanism	0.85
Familiar Context Stress	upregulates	process	0.85
h-1e564178	targets	hypothesis	0.80
STRESS	activates	phenotype	0.72
AVP	interacts_with	gene	0.70
OLFACTORY_CUES	activates	phenotype	0.64
ALZHEIMER	activates	disease	0.64
NR3C1	interacts_with	gene	0.61
TNFA	interacts_with	gene	0.61
BDNF	co_mentioned_with	gene	0.60
IL18	activates	gene	0.60
RAMP1	inhibits	gene	0.60
FKBP5	activates	gene	0.60
UROCORTIN	associated_with	gene	0.60
CRHR1	interacts_with	gene	0.60
TNF	associated_with	gene	0.60
JUN	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
FKBP5	interacts_with	gene	0.60
AVP	expressed_in	gene	0.60
POMC	expressed_in	gene	0.60
CRHR1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ESR2	expressed_in	gene	0.60
JUN	activates	gene	0.60
ESR1	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
CRHR1	inhibits	gene	0.60
CALCA	inhibits	gene	0.60
BDNF	activates	gene	0.60
NR3C1	inhibits	gene	0.60
POMC	regulates	gene	0.60
ARC	regulates	gene	0.60
CRHR1	activates	gene	0.60
HTR1A	activates	gene	0.60
CLOCK	activates	gene	0.60
CRHR1	associated_with	gene	0.60
TNF	activates	gene	0.60
NPY	activates	gene	0.60
BDNF	upregulates	entity	0.60
IL18BP	inhibits	gene	0.60
NTS	regulates	gene	0.60
NPY	regulates	gene	0.60
AVP	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
TAU	therapeutic_target	gene	0.60
AVP	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CRH

Understanding Entity Pages

Summary

Wiki Pages (21)

Edinger-Westphal Nucleus in Pupillary Reflex

cerebral-cortical-vasal-neurons

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Paraventricular Hypothalamic Nucleus (PVN) Neurons

Tuberoinfundibular Dopamine Neurons in Parkinson's Disease

HPA Axis Dysfunction in Neurodegeneration

Glucocorticoid Signaling Pathway in Neurodegeneration

cortisol-tau-pathway

Oxytocin Receptor Neurons

Testosterone Signaling in Neurodegeneration

Biomarkers of Alzheimer Disease

Biomarker-Therapeutic Development Nexus

Hypothalamic-Pituitary-Adrenal Axis

Biomarkers in Neurodegeneration

Neuropeptide Y (NPY) Neurons

Actinogen Medical

Biomarkers for Parkinson's Disease

paraventricular-nucleus-autonomic

Locus Coeruleus Noradrenergic Neurons

Hypothalamus