Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about synaptic activity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| BDNF | regulates | protein | 0.88 |
| synapsin-1 phosphorylation | activates | mechanism | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 30344044 | reduces | paper | 0.90 |
| Tardbp | regulates | protein | 0.90 |
| TARDBP | associated_with | protein | 0.90 |
| Microglia | regulates | cell_type | 0.85 |
| Microglia | associated_with | cell_type | 0.85 |
| LRRK2 | regulates | gene | 0.85 |
| INFLAMMATORY FACTORS | disrupts | protein | 0.80 |
| Senolytics | associated_with | drug | 0.80 |
| Autophagy | modulates | process | 0.80 |
| Mitochondrial dysfunction | inhibits | process | 0.70 |
| 21358643 | encode proteins involved in | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 3 hypotheses Top: 0.455
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.68 · 2026-04-12
closed · Rounds: 4 · Score: 0.56 · 2026-04-11
Hypotheses and analyses mentioning synaptic activity in their description or question text
No additional research found