Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about tau release: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| calcium influx | causes | mechanism | 0.70 |
| CDK5 inhibition | inhibits | mechanism | 0.70 |
| calcium influx | activates | mechanism | 0.70 |
| synaptic vesicle cycling | regulates | phenotype | 0.70 |
| neuronal activity | modulates | process | 0.70 |
| synaptotagmin-1 | modulates | protein | 0.70 |
| Il-1Β | causes | protein | 0.70 |
| extracellular vesicles | modulates | process | 0.70 |
| NEURONAL_ACTIVITY | activates | phenotype | 0.70 |
| NMDAR | regulates | protein | 0.70 |
| CaMKII | regulates | protein | 0.70 |
| BIN1 | modulates | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CDK5 Inhibition at Presynaptic Terminals Prevents Activity-D | 0.640 | neurodegeneration | Investigate prion-like spreading of tau |
| Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau | 0.620 | neurodegeneration | Investigate prion-like spreading of tau |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-07 | 6 hypotheses Top: 0.740
neuroscience | 2026-04-04 | 9 hypotheses Top: 0.822
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.640
neurodegeneration | 2026-04-04 | 18 hypotheses Top: 0.814
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.34 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
Hypotheses and analyses mentioning tau release in their description or question text
No additional research found