concept

NMDAR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMDAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

105Connections

3Hypotheses

1Analyses

47Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	NMDAR
Key Genes/Proteins	ABETA, AKT, APOE, APOE4, APP, ASC
Related Diseases	ALZHEIMER, Alzheimer's disease, ALZHEIMER'S DISEASE
Related Pathways	apoptosis pathway, autophagy pathway
Linked Hypotheses	3 hypotheses

Pathway Diagram

graph TD
    NMDAR[NMDAR]
    NMDAR -->|mediates| Activity_Dependent_Synaptic_Pl[Activity-Dependent Synaptic Plasticity]
    NMDAR -->|activates| pro_BDNF_Signaling[pro-BDNF Signaling]
    NMDAR -->|expressed in| neurons[neurons]
    NMDAR -.protects against.-> APP[APP]
    NMDAR -->|activates| AKT[AKT]
    NMDAR -->|activates| NEURODEGENERATION[NEURODEGENERATION]
    NMDAR -->|expressed in| SST[SST]
    NMDAR -->|activates| TLR2[TLR2]
    NMDAR -->|activates| TLR4[TLR4]
    EEF2[EEF2] -->|inhibits| NMDAR
    Ketamine[Ketamine] -->|inhibits| NMDAR
    ABETA[ABETA] -->|activates| NMDAR
    APOE[APOE] -->|activates| NMDAR
    SYNAPTIC_PLASTICITY[SYNAPTIC PLASTICITY] -->|activates| NMDAR
    MEMANTINE[MEMANTINE] -->|inhibits| NMDAR
    SST_INs[SST-INs] -->|expressed in| NMDAR

Outgoing (47)

Target	Relation	Type	Str
Activity-Dependent Synaptic Plasticity	mediates	process	0.85
pro-BDNF Signaling	activates	pathway	0.80
Alzheimer's disease	associated_with	disease	0.70
tau release	regulates	phenotype	0.70
neurons	expressed_in	cell_type	0.70
AKT	activates	gene	0.65
APP	protects_against	gene	0.65
APP	treats	gene	0.65
NEURODEGENERATION	activates	phenotype	0.65
stroke	implicated_in	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60
PV	expressed_in	gene	0.60
schizophrenia	inhibits	disease	0.60
schizophrenia	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
synaptic plasticity	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
Parkinson's disease	interacts_with	disease	0.60
TLR2	activates	gene	0.60
TLR4	activates	gene	0.60
neurodegeneration	interacts_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
schizophrenia	causes	disease	0.60
epilepsy	causes	disease	0.60
glutamate signaling	participates_in	pathway	0.60
neurodegeneration	activates	disease	0.60
SST	expressed_in	gene	0.60
epilepsy	activates	disease	0.60
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
MAPK signaling	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
RNA	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
NEURODEGENERATION	regulates	phenotype	0.56
PSD-95	associated_with	gene	0.55
ALZHEIMER'S DISEASE	implicated_in	disease	0.55
neurotrophin signaling	participates_in	pathway	0.55
PS1	activates	gene	0.55
PSD-95	activates	gene	0.55
CA1	associated_with	brain_region	0.50
CA3	associated_with	brain_region	0.50

Incoming (58)

Source	Relation	Type	Str
EEF2	inhibits	gene	0.90
Ketamine	inhibits	drug	0.90
ABETA	activates	protein	0.80
SYNAPTIC PLASTICITY	activates	phenotype	0.70
APOE	activates	gene	0.70
APOE	regulates	gene	0.70
MEMANTINE	inhibits	drug	0.65
MEMANTINE	regulates	drug	0.65
MEMANTINE	treats	drug	0.65
SST-INs	expressed_in	cell_type	0.60
CYP46A1	protects_against	gene	0.60
CYP46A1	associated_with	gene	0.60
CYP46A1	regulates	gene	0.60
HMGCR	regulates	gene	0.60
CYP46A1	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
GABA	associated_with	gene	0.60
MAPK	protects_against	gene	0.60
EAAT2	associated_with	gene	0.60
EAAT2	activates	gene	0.60
NMDA	causes	gene	0.60
NLRP3	activates	gene	0.60
HDAC1	activates	gene	0.60
APP	regulates	gene	0.60
GDNF	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
memantine	targets	drug	0.60
CD14	activates	gene	0.60
APOE4	regulates	gene	0.60
AKT	activates	gene	0.60
ASC	activates	gene	0.60
ATF3	activates	gene	0.60
ATG5	activates	gene	0.60
CCR2	activates	gene	0.60
CHOP	activates	gene	0.60
IRAK1	activates	gene	0.60
ISG15	activates	gene	0.60
JNK	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3	activates	gene	0.60
MLKL	activates	gene	0.60
SYNAPTIC PLASTICITY	implicated_in	phenotype	0.60
GRIN2A	associated_with	gene	0.60
MAPK	activates	gene	0.60
NLR	activates	gene	0.60
IFN	regulates	gene	0.60
LAMP2B	interacts_with	gene	0.60
ASK1	activates	gene	0.60
ERK	activates	gene	0.60
IFN	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Fyn-anchored dendritic tau/NMDAR signaling persists after tr	0.670	neurodegeneration	Does tau dendritic missorting persist in
Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau	0.620	neurodegeneration	Investigate prion-like spreading of tau
Synaptic NMDAR Subtype Targeting Prevents Excitotoxicity	0.520	neurodegeneration	Test Preregistration Analysis

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which tau propagation mechanism predominates in different brain regions and dise

neurodegeneration | 2026-04-07 | 6 hypotheses Top: 0.740

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate considered multiple propagation routes (synaptic, extracellular vesic

closed · Rounds: 4 · Score: 0.66 · 2026-04-21

Related Research

Hypotheses and analyses mentioning NMDAR in their description or question text

No additional research found