Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NMDAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Activity-Dependent Synaptic Plasticity | mediates | process | 0.85 |
| pro-BDNF Signaling | activates | pathway | 0.80 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| neurons | expressed_in | cell_type | 0.70 |
| APP | protects_against | gene | 0.65 |
| APP | treats | gene | 0.65 |
| AKT | activates | gene | 0.65 |
| NEURODEGENERATION | activates | phenotype | 0.65 |
| SST | expressed_in | gene | 0.60 |
| TLR2 | activates | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| neurodegeneration | interacts_with | disease | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| schizophrenia | causes | disease | 0.60 |
| epilepsy | causes | disease | 0.60 |
| glutamate signaling | participates_in | pathway | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| epilepsy | activates | disease | 0.60 |
| PV | expressed_in | gene | 0.60 |
| schizophrenia | inhibits | disease | 0.60 |
| schizophrenia | associated_with | disease | 0.60 |
| stroke | implicated_in | disease | 0.60 |
| PARKIN | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| blood-brain barrier | participates_in | pathway | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.60 |
| Parkinson's disease | interacts_with | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| Alzheimer's disease | activates | disease | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| RNA | activates | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| necroptosis | participates_in | pathway | 0.60 |
| NEURODEGENERATION | regulates | phenotype | 0.56 |
| neurotrophin signaling | participates_in | pathway | 0.55 |
| ALZHEIMER'S DISEASE | implicated_in | disease | 0.55 |
| PSD-95 | associated_with | gene | 0.55 |
| PS1 | activates | gene | 0.55 |
| PSD-95 | activates | gene | 0.55 |
| CA1 | associated_with | brain_region | 0.50 |
| CA3 | associated_with | brain_region | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| EEF2 | inhibits | gene | 0.90 |
| Ketamine | inhibits | drug | 0.90 |
| ABETA | activates | protein | 0.80 |
| APOE | activates | gene | 0.70 |
| APOE | regulates | gene | 0.70 |
| SYNAPTIC PLASTICITY | activates | phenotype | 0.70 |
| MEMANTINE | inhibits | drug | 0.65 |
| MEMANTINE | regulates | drug | 0.65 |
| MEMANTINE | treats | drug | 0.65 |
| SST-INs | expressed_in | cell_type | 0.60 |
| CD14 | activates | gene | 0.60 |
| HDAC1 | activates | gene | 0.60 |
| APP | regulates | gene | 0.60 |
| GDNF | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| memantine | targets | drug | 0.60 |
| GRIN2A | associated_with | gene | 0.60 |
| APOE4 | regulates | gene | 0.60 |
| CYP46A1 | protects_against | gene | 0.60 |
| CYP46A1 | associated_with | gene | 0.60 |
| CYP46A1 | regulates | gene | 0.60 |
| HMGCR | regulates | gene | 0.60 |
| CYP46A1 | inhibits | gene | 0.60 |
| HMGCR | inhibits | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| ASC | activates | gene | 0.60 |
| ATF3 | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| CCR2 | activates | gene | 0.60 |
| CHOP | activates | gene | 0.60 |
| IRAK1 | activates | gene | 0.60 |
| ISG15 | activates | gene | 0.60 |
| JNK | activates | gene | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MLKL | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| GABA | associated_with | gene | 0.60 |
| SYNAPTIC PLASTICITY | implicated_in | phenotype | 0.60 |
| MAPK | protects_against | gene | 0.60 |
| IFN | regulates | gene | 0.60 |
| EAAT2 | associated_with | gene | 0.60 |
| EAAT2 | activates | gene | 0.60 |
| NMDA | causes | gene | 0.60 |
| LAMP2B | interacts_with | gene | 0.60 |
| ASK1 | activates | gene | 0.60 |
| ERK | activates | gene | 0.60 |
| IFN | activates | gene | 0.60 |
| MAPK | activates | gene | 0.60 |
| NLR | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||